Clinical study on the treatment of multi-drug resistant pulmonary tuberculosis syndrome of Yin and Yang deficien-cy syndrome by Bufei-antituberculosis prescription combined with Dihuang Yinzi plus reduction combined with garlic moxibustion and standard ant
Objective To investigate the clinical efficacy of Bufei anti-tuberculosis prescription combined with Dihuang Drink combined with garlic moxibustion and standard anti-tuberculosis regimen in the treatment of multidrug resistant pulmonary tuber-culosis(MDR-PTB)with yin-yang deficiency syndrome.Methods 124MDR-PTB patients with Yin-yang deficiency syndrome admitted to our hospital from January 2021to January 2023were selected as the study objects,and were divided into observation group and control group with 62cases in each group according to random number table method.Control group was treated with standard anti-tuberculosis regimen[6Lfx(Mfx)-Bdq(Lzd)-Cfz-Cs-Z(E,Pto)/12～14Lfx(Mfx)-Cfz-Cs-Z(E,Pto);Lfx:Levofloxacin,Mfx:Moxifloxacin,Bdq:Bedaquinoline,Lzd:Linzolid,Cfz:Clofazimine,Cs:cycloserine,Z:pyrazi-namide,E:ethambutol,Pto:propylthioisonicamide]treatment,observation group on the basis of the control group combined with the self-designed bufu antituberculosis prescription combined with Dihuang Drink and garlic moxibustion treatment,after continuous treatment for 12weeks to evaluate the efficacy of the two groups.TCM syndrome score before and after treatment,spu-tum negative conversion rate,lesion absorption rate and cavity shrinkage rate were compared between the two groups.Serum in-flammatory markers[soluble myeloid cell trigger receptor-1(sTREM-1),matrix metalloproteinase-9(MMP-9),interleukin-18(IL-18)]and peripheral blood cell immune function indicators[percentage of CD3+T cells,CD4+T cells,CD8+T cells,and CD4+/CD]were detected before and after treatment 8+ratio].The adverse reactions of the two groups were analyzed.Re-sults The total effective rate of the observation group was 93.55％,which was significantly higher than that of the control group(75.81％,P＜0.05).After treatment,the scores of cold limbs,night sweats,spontaneous sweats,hot flusher,floating face and swollen limbs,cough and counter-breathing and shortness of breath in two groups were significantly decreased compared with those before treatment(P＜0.05),and the observation group was the only group(P＜0.05).After 12weeks of treatment,the spu-tum negative conversion rate,focal absorption rate and cavity shrinkage rate in the observation group were 53.23％,64.52％and 59.68％,respectively,which were significantly higher than those in the control group(35.48％,45.16％and 40.32％)(P＜0.05).After treatment,the levels of serum sTREM-1,MMP-9,IL-18and peripheral blood CD8+in observation group were significantly lower than those in control group(P＜0.05),and the levels of peripheral blood CD3+,CD4+and CD4+/CD8+ratio in observation group were significantly higher than those in control group(P＜0.05).The incidence of adverse reactions in obser-vation group(33.87％)was significantly lower than that in control group(58.06％,P＜0.05).Conclusion The self-prepared Bufei-antituberculosis prescription combined with Dihuang Yinzi combined with garlic moxibustion and standard anti-tuberculosis regimen can effectively reduce the inflammation in the body,improve cellular immune function,promote sputum to negative and lesion absorption,and improve clinical efficacy.
Self-designed supplementing lung and anti-tuberculosis prescriptiondihuang drinkMoxibustion with garlicStandard anti-tuberculosis protocolMultidrug-resistant tuberculosisYin-yang deficiency syndrome
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