Effects of Shenqi Jiedu Decoction combined with GP chemotherapy on immune function and long term survival of patients with advanced non-small cell lung cancer
Objective:To investigate the effects of Shenqi Jiedu Decoction combined with GP chemotherapy regimen on long-term survival and immune function of patients with advanced non-small cell lung cancer(NSCLC).Methods:109patients with advanced NSCLC admitted to our hospital were randomly divided into Shenqi Jiedu decoction group(n=55)and control group(n=54).The control group was treated with gemcitabine combined with cisplatin,and the Shenqi Jiedu decoction group was treated with Shenqi Jiedu decoction on the basis of the control group.The short-term efficacy,peripheral blood T lymphocyte subsets and serum tumor markers of the two groups were compared,and the long-term survival of the two groups after treatment was analyzed.Results:The disease control rate and total effective rate of Shenqi Jiedu decoction group were significantly higher than those of control group(P＜0.05).After chemotherapy,the ratio of CD3+,CD4+and CD4+/CD8+in 2groups was significantly decreased compared with that before chemotherapy(P＜0.05),and the percentage of CD8+cells was significantly increased compared with that before chemotherapy(P＜0.05).After chemotherapy,the ratio of CD3+,CD4+and CD4+/CD8+in Shenqi Jiedu Decoction group was significantly higher than that in control group(P＜0.05),while the percentage of CD8+cells was significantly lower than that in control group(P＜0.05).After treatment,serum tumor markers NSE,CYFRA21～1and CA199were significantly de-creased in both groups compared with before treatment(P＜0.05),and after treatment,serum NSE,CYFRA21～1and CA199in Shenqi Jiedu decoction group were significantly lower than those in control group(P＜0.05).The incidence of grade Ⅲ to Ⅳ seri-ous adverse reactions in Shenqi Jiedu decoction group was significantly lower than that in control group(P＜0.05).The median follow-up survival time of Shenqi Jiedu Decoction group was 14.23months,and that of control group was 10.38months.The over-all survival of Shenqi Jiedu Decoction group was significantly better than that of control group(P＜0.05).Conclusion:Shenqi Jidu Decoction combined with GP chemotherapy has significant clinical efficacy,which can effectively improve the immune func-tion of patients,reduce the level of serum tumor markers,and help improve the long-term survival prognosis of patients,which is worthy of clinical promotion.
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