Effect and clinical study of Shenqi Yiqi Yangxue Decoction in the treatment of cancer-related fatigue in patients af-ter gastric cancer chemotherapy
Objective To explore the curative effect of Shenqi Yiqi Yangxue Decoction on cancer-related fatigue(CRF)in patients after gastric cancer chemotherapy.Methods A total of 94patients with CRF after gastric cancer chemotherapy in the hospi-tal were enrolled as the research objects.They were randomly divided into control group and treatment group,47cases in each group.The control group was given routine chemotherapy,while treatment group was additionally treated with Shenqi Yiqi Yangx-ue Decoction.The scores of TCM symptoms and Piper Fatigue Scale(PFS),immune function indexes[natural killer(NK)cells,CD4+cells,CD8+cells]and inflammatory indexes[C-reactive protein(CPR),interleukin-4(IL-4),interleukin-6(IL-6)]before and after treatment,and adverse reactions during treatment were compared between the two groups.Results Af-ter treatment,scores of TCM symptoms in both groups were decreased,which were lower in treatment group than control group(P＜0.05).After treatment,PFS score in both groups was decreased,which was lower in treatment group than control group(P＜0.05).After treatment,NK and CD4+levels were decreased,while CD8+level was increased in both groups.NK and CD4+levels in treatment group were higher than those in control group,while CD8+level was lower than that in control group(P＜0.05).Af-ter treatment,levels of CPR,IL-4and IL-6in both groups were decreased,which were lower in treatment group than control group(P＜0.05).During treatment,there was no significant difference in the safety between the two groups(P＞0.05).Conclu-sion Shenqi Yiqi Yangxue Decoction can relieve TCM symptoms and fatigue,enhance immune function and inhibit inflammatory response in patients with CRF after gastric cancer chemotherapy,with good safety.
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