Effects of added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets on headache symp-toms and plasma 5-HT,VEGF,CGRP in patients with migraine
Objective:To explore the effects of added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets on headache symptoms,plasma 5-hydroxytryptamine(5-HT),vascular endothelial growth factor(VEGF)and calcitonin gene-related peptide(CGRP)in migraine patients.How:A total of 120migraine patients admitted to our hospital from April 2020to April 2022were grouped according to random number table method.In the control group,60cases were treated with aspirin enteric-coated tablets,and in the study group,60cases were treated with added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets.To evaluate the clinical efficacy of the two groups,compare the levels of headache,plasma 5-HT,VEGF,CGRP and inflammatory factors before and after treatment between the two groups,and observe the adverse reactions of the two groups.Result:The total effective rate of the study group was higher than that of the control group(P＜0.05).After treat-ment,the headache symptoms of the study group were significantly relieved compared with the control group(P＜0.05).After treatment,the levels of VEGF,CGRP,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the study group were lower than those in the control group,and the levels of 5-HT were higher than those in the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).Con-clusion:Added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets has significant efficacy and high safety in the treatment of migraine patients,which can effectively relieve the headache symptoms of patients,regulate the levels of plasma 5-HT,VEGF and CGRP,and reduce the levels of inflammatory factors.
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