Efficacy of Wenyang Shufeng Decoction combined with levoxetirizine in the treatment of chronic urticaria and itsef-fect on serum MCP、PARC/CCL-18
Objective To observe the efficacy of Wenyang Shufeng decoction combined with levocetirizine in the treatment of chronic urticaria and its effect on serum monocyte chemoattractant protein(MCP)and lung activation regulating chemokine/che-mokine ligand 18(PARC/CCL-18)in the treatment of chronic urticaria.Methods 130patients with chronic urticaria admitted in our hospital in October 2020～May 2023were divided into two groups according to the treatment method,65cases in each group.The control group was treated with levoxetirizine,and the observation group was treated with Wenyang Shufeng decoction com-bined with levoxetirizine.The scores of quality of life index(DLQI)and the changes of Th1/Th2factors and MCP、PARC/CCL-18were recorded groups were recorded.Results A total effective rate of 95.38％in the observation group was higher than that in the control group(P＜0.05).Two groups of interferon-γ(IFNγ)increased after treatment(P＜0.05),Monocyte chemoattrac-tant protein-1(MCP-1),monocyte chemoattractant protein-3(MCP-3),PARC/CCL-18,interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)decreased compared to pre-treatment(P＜0.05),The IFN-γ in the ob-servation group was higher than that in the control group(P＜0.05)and the MCP、PARC/CCL-1、IL-4、TNF-α、IL-10was lower than that in the control group(P＜0.05).The DLQI scores of the two groups(including symptoms and feelings,interper-sonal relationships,leisure activities,daily activities,work and study,and clinical treatment)decreased after treatment(P＜0.05),and the DLQI scores of the observation group were lower than those of the control group(P＜0.05).Compared with the two groups,there was no statistical significance(P＞0.05).Conclusion Wenyang Shufeng decoction combined with levoxetirizine in the treatment of chronic urticaria can improve the efficacy and quality of life,which may be related to the expression of Th1/Th2factors and MCP、PARC/CCL-18.
Warm Yang Shufeng TangLevocetirizineChronic urticariaMonocyte chemoattractant proteinQuality of life
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