Effect of Wenfei Tongluo Experience Prescription combined with salbutamol on the X、VⅡ activity of coagulation factors in patients with chronic pulmonary embolism and phlegm stasis syndrome
Objective:Effect of Wenfei Tongluo prescription combined with salbutamol on coagulation factor X、VⅡactivity of chronic pulmonary embolism phlegm and blood stasis syndrome was observed.Methods:A total of 106patients with chronic pulmonary embolism admitted to our hospital from April 2017to May 2020(syndrome of phlegm-stasis interassociation as the type of TCM syndrome differentiation)were selected and grouped according to their treatment plan.53patients in the control group were given atomized salbutamol inhalation therapy on the basis of anticoagulation,anti-infection and phlegm reduction,and 53patients in the observation group were given the empirical treatment of Wen Feitonglu decoction on the basis of the control group.The changes of TCM syndrome scores,inflammatory factors,coagulation related factors,pulmonary artery pressure and the predicted value of forced expiratory volume in the first second(FVE1)were recorded in the two groups.Results:After treatment,cough,chest tightness,dyspnea,blue lip nails,loss of appetite and the total score of TCM syndrome of the two groups were significantly decreased(P＜0.05),and the total score of TCM syndrome of the observation group was lower than that of the control group(P＜0.05).After treatment,fibrinogen(FIB)and platelet count(PLT)in both groups were significantly increased,while the activ-ities of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),coagulation factor X,VⅡand D-dimer(D-D)were sig-nificantly decreased(P＜0.05).After treatment,FIB and PLT in observation group were higher than those in control group,and the activities of TNF-α,IL-1β,clotting factor X,VⅡand D-D in observation group were lower than those in control group(P＜0.05).After treatment,the predicted value of FVE1increased significantly(P＜0.05),and the pulmonary artery pressure de-creased significantly(P＜0.05),and the predicted value of FVE1in the observation group was higher than that in the control group,and the pulmonary artery pressure was lower(P＜0.05).Conclusion:In the treatment of chronic pulmonary embolism syndrome of phlegm-stasis interjunction with salbutamol,Wenfei Tongluo experience formula combined with salbutamol can im-prove the expression of coagulation related factors,reduce inflammatory reaction and clinical symptoms,and improve lung func-tion.
Wenfei Tongluo experience prescriptionSalbutamolChronic pulmonary embolismSyndrome of phlegm and blood stasisCoagulation factor
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维普
