The effect of the tumor on the treatment of the different syndromic cells in the late phase of the small cell lung canc-er
objective:to analyze the therapeutic of FuzhengYiyufang combined with programmed cell death protein(PD-1)and ligand1(PD-L1)inhibitor on different syndrome types of advanced non-small cell lung cancer(NSCLC).Methods:A total of 137NSCLC patients who received FuzhengYiyufang combined with PD-1/PD-L1inhibitors were classified,and clinical data of the patients were collected to make statistics on Progression-free Survival(PFS).Functional status(Karnofsky,KPS)score and TCM syndrome score were used to evaluate and analyze the functional status and syndrome changes of patients after 4weeks of treatment.Results:Among the selected patients,there were 30cases(21.74%)of lung qi deficiency,46cases(33.33%)of qi deficiency and phlegm-dampness,34cases(24.64%)of qi and blood stasis,and 28cases(20.29%)of qi Yin deficiency.Over-all median media Progression-free Survival(mPFS)was6.0months(95%CI:4.5～8.4).The highest mPFS in Qi-blood stasis syndrome was 7.8months(95%CI:5.5～10.0),and the lowest mPFS in Qi-yin deficiency syndrome was only 4.5months(95%CI:3.0～4.8).There was significant difference in mPFS among different syndrome types(x2=15.527,P＜0.01).After 4weeks of treatment,the Objective Response Rate(ORR)was 23.66%,and the Disease Control Rate(DCR)was 62.6%.After 4cycles of treatment,the total improvement rate of KPS score in the four syndrome groups was 63.36%.The improvement rate of KPS in patients with Qi-blood stasis syndrome was the highest(76.67%),followed by Qi-deficiency phlegm-dampness 72.73%.The improvement rate of KPS in patients with Qi-Yin deficiency syndrome was the lowest(35.71%).The difference between the four syndrome groups was statistically significant.Qi-deficiency phlegm-dampness and Qi-blood stasis were signifi-cantly higher than Qi-yin deficiency(P＜0.01).The effective rate of improvement of TCM score was 63.36%in the four syn-drome groups after 4cycles of treatment.The effective rate of lung Qi deficiency was 34.48%;The effective rate of Qi deficiency and phlegm dampness was 36.36%.The effective rate of Qi and blood stasis was 60%;The effective rate of Qi-Yin deficiency was 25%.The effective rate of the four syndrome types was significantly different,and Qi-blood stasis syndrome was significantly higher than other syndrome types(P＜0.05).The incidence of adverse reactions was 83.97%.It mainly includes fatigue,skin itching,redness,blisters,pneumonia,liver,kidney,thyroid,heart function abnormalities,gastrointestinal adverse reactions and bone marrow suppression.Conclusion:Non-small cell lung cancer can be mainly divided into lung Qi deficiency syndrome,Qi deficiency phlegm-dampness syndrome,qi and blood stasis syndrome,Qi-Yin deficiency syndrome.Fuzhengyioma prescription combined with PD-1/PD-L1inhibitor has different therapeutic effects on different syndrome types,and Qi-yin deficiency syn-drome has the worst therapeutic effect.
万方数据
维普
