Effects ofmodified Chaihu Wenjing Decoction on scores of TCM symptoms,neurotransmitters and inflammatory factors in patients with perimenopausal insomnia(liver-depression yin-deficiency and blood stasis type)
Objective To explore the effects of modified Chaihu Wenjing Decoction on scores of TCM symptoms,neurotrans-mitters and inflammatory factors in patients with perimenopausal insomnia(liver-depression yin-deficiency and blood stasis type).Methods A total of 102patients with perimenopausal insomnia of liver-depression yin-deficiency and blood stasis type ad-mitted to the hospital were enrolled as the research objects between December 2021and December 2022.According to random number table method,they were divided into control group(51cases)and study group(51cases).The control group was treated with routine western medicines,while study group was treated with modified Chaihu Wenjing Decoction for 8weeks.The curative effect,changes in scores of TCM symptoms(chronic insomnia,forgetfulness,irritability,skin itching,fatigue and ache),levels of neurotransmitters[β-endorphin(β-EP),neuropeptide Y(NPY),5-hydroxytryptamine(5-HT)]and inflammatory fac-tors[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],sleep structure[total sleep time(TST),sleep latency(SL),sleep efficiency(SE),awakening time(AT)]and incidence of adverse reactions were compared between the two groups.Results After 8weeks of treatment,total response rate of study group was higher than that of control group(P＜0.05).After treatment,scores of TCM symptoms in both groups were decreased(P＜0.05),whichwerelower instudygroup than control group(P＜0.05).After treatment,levels of NPY,β-EP and5-HT were increased,while levels of TNF-α,IL-1β and IL-6were decreased in both groups(P＜0.05),and the change amplitude was greater in study group than control group(P＜0.05).After treatment,TST and SE were increased,while SL and AT were decreased in both groups(P＜0.05),and the change amplitude was greater in study group than control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The curative effect of modified Chaihu Wenjing Decoction is significant in patients with perimenopausal insomnia(liver-depression yin-deficiency and blood stasis type),which can effectively improve TCM symptoms,increase levels of neurotransmitters,reduce levels of inflammatory factors and optimize sleep structure.
Perimenopausal insomniaLiver-depression yin-deficiency and blood stasis typeModified Chaihu Wenjing Decoctionscore of TCM symptomNeurotransmitterInflammatory factor
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