首页|基于R语言软件挖掘姚魁武教授辨治高血压组方用药规律研究

基于R语言软件挖掘姚魁武教授辨治高血压组方用药规律研究

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目的:基于R语言软件分析首都中青年名中医、中国中医科学院博士研究生导师姚魁武教授辨治高血压组方用药规律.方法:筛选姚魁武教授2021年1月~2023年10月门诊治疗高血压病的病案,检索并收集主诊断为高血压患者的临床病历资料及中医处方信息,通过EXCE1 2019软件构建高血压患者门诊病历数据库,归纳分析患者年龄性别、中医证型、中药性味归经、药物关联规则、高频药物相关性及聚类分析.结果:共筛选出324位患者病历信息,年龄以40~70岁频数最多;涵盖中医证型16种,频数前五的中医证型为肝阳上亢证、痰瘀互结证、肝肾阴虚证、肝郁脾虚证、气滞血瘀证;使用中药139味,使用频数前10的中药为葛根、天麻、川芎、白芍、茯苓、桂枝、丹参、白术、珍珠母、杜仲,四气以寒、温、平为主,五味以甘、苦、辛居多,归经则集中在肝、心、脾、肺、肾、胃经;使用频数≥60的中药共有33味;设置支持度≥15%,置信度≥90%,得到关联规则33个;相关性分析获得较强关联的药物12组;聚类分析共得到9类.结论:姚魁武教授临床治疗高血压病以"和合思想"为主,用药重在调肝脾、合阴阳,随证配伍兼顾补虚、清热、活血化瘀、祛浊化痰等法,为临床治疗高血压病提供新的思路与指导.
Research on the Hypertension Prescription Rule of Professor Yao Kuiwu based on R Language/
Objective:Based on R language software analysis,Professor Yao Kuiwu,a renowned traditional Chinese medi-cine practitioner and doctoral supervisor at the Chinese Academy of Traditional Chinese Medicine in the capital,identified the medication patterns in the differentiation and treatment of hypertension.Method:Professor Yao Kuiwu's outpatient treatment of hy-pertension from January 2021to October 2023was screened,and clinical medical records and traditional Chinese medicine pre-scription information of patients diagnosed with hypertension were retrieved and collected.A database of outpatient medical records of hypertension patients was constructed using EXCEl2019software,and the patient's age and gender,traditional Chinese medi-cine syndrome types,traditional Chinese medicine characteristics and tastes,meridians,drug association rules,high-frequency drug correlation,and cluster analysis were summarized and analyzed.Result:A total of 324 patients were screened for medical re-cord information,with the highest frequency occurring between the ages of 40~70;Covering 16types of traditional Chinese medi-cine syndromes,the top five frequent TCM syndromes are liver yang hyperactivity syndrome,phlegm stasis syndrome,liver kidney yin deficiency syndrome,liver depression and spleen deficiency syndrome,and qi stagnation and blood stasis syndrome;139traditional Chinese medicines are used,with the top 10most frequently used herbs being Pueraria lobata,Tianma,Chuanx-iong,White Peony,Poria cocos,Guizhi,Danshen,Atractylodes macrocephala,Mother of Pearl,and Eucommia ulmoides.The four qi are mainly cold,warm,and flat,while the five flavors are mostly sweet,bitter,and spicy.The meridians are concentrated in the liver,heart,spleen,lungs,kidneys,and stomach meridians;There are a total of 33traditional Chinese medicines with a usage frequency of ≥ 60;Set support level≥15%,confidence level≥90%,and obtain 33association rules;12groups of drugs with strong correlation were obtained through correlation analysis;Cluster analysis yielded a total of 9categories.Conclusion:Pro-fessor Yao Kuiwu's clinical treatment of hypertension is mainly based on the concept of"harmony and harmony".The emphasis of medication is on regulating the liver and spleen,integrating yin and yang,and combining with syndrome to supplement deficien-cy,clear heat,promote blood circulation and remove stasis,and dispel turbidity and phlegm.This provides new ideas and guid-ance for the clinical treatment of hypertension.

hypertensionMedication patternsYao KuiwuR languagedata mining

逯晓阳、姚魁武、刘思琛、孙迪、徐思雨、段锦龙

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中国中医科学院广安门医院,北京 100053

中国中医科学院眼科医院,北京 100000

高血压 用药规律 姚魁武 R语言 数据挖掘

2024

四川中医
四川省中医药学会,四川省中西医结合学会,四川省针灸学会,四川省中医药科学院

四川中医

CSTPCD
影响因子:0.522
ISSN:1000-3649
年,卷(期):2024.42(8)