Clinical Observation and Mechanism Exploration of Lishangqufeng Decoction in Treating Severe Corneal Edema af-ter Cataract Surgery
Objective To observe the changes of ocular symptoms and inflammation-related indicators in patients with severe corneal edema after phacoemulsification cataract surgery treated with Lishang Qufeng Decoction,analyze the therapeutic effect of Lishang Qufeng Decoction,and reveal the possible mechanism of its treatment of this disease.Methods According to random sam-pling method,60patients with severe corneal edema after surgery admitted to Department of Ophthalmology of Bozhou City of Tra-ditional Chinese Medicine from March 2022to September 2023were divided into control group and control group(n=30,conven-tional treatment)and observation group(n=30,the control group was treated with Lishang Qufeng Decoction on the basis of treatment),and all patients received phacoemulsification cataract surgery;the clinical therapeutic effect and disappearance time of corneal edema of the two groups were observed and compared,and the visual acuity,corneal thickness,corneal endothelial cell variation and serum inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8)]of the two groups were compared before treatment and 1 month after treatment.Results Compared with the control group,the total effec-tive rate in the observation group was higher(P＜0.05).Edema disappearance time was 5.5(4.75～8.00)days in observation group and 10.5(5-15)days in control group,and the observation group was shorter than the control group,with statistical sig-nificance(Z=-2.632,P=0.008).The visual acuity of observation group was 1.4(0.8～3.0)before treatment and 0.55(0.300～0.925)after treatment;the visual acuity of control group was 0.9(0.6～2.0)before treatment and 0.4(0.3～0.7)after treatment;there was no significant difference in visual acuity between the two groups before and after treatment(P＞0.05).One month after treatment,the corneal thickness of the observation group was lower than that of the control group(P＜0.05),and the variation of corneal endothelial cells of the observation group was lower than that of the control group(P＜0.05).One month after treatment,the levels of IL-6and IL-8in the observation group were lower than those inthe control group(P＜0.05),and there was no significant difference in IL-β between the two groups(P＞0.05).Conclusion Lishangqufeng decoction can signifi-cantly improve the clinical therapeutic effect,and improve the visual acuity and corneal endothelial cell variation after treatment by reducing the inflammatory reaction of the body.
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