Influence of modified Xiaochaihu decoction based on time rhythm on airway inflammation level in children with cough variant asthma
ObjectiveTo observe the influence of modified Xiaochaihu decoction based on time rhythm on airway inflammation levels in children with cough variant asthma(CVA)of lung qi deficiency syndrome.Methods 136 children with CVA of lung qi deficiency syndrome in our hospital were selected as the research subjects from May 2021 to May 2023,and were randomly divid-ed into control group(n=68)and traditional Chinese medicine group(n=68)according to the random number table method.The control group was treated with Xiaoer Zhixiaoling tablets,while the traditional Chinese medicine group was given modified Xi-aochaihu decoction combined with 24 solar terms.The clinical efficacy after 2 weeks of treatment and TCM symptoms scores and airway inflammation level before treatment and after 2 weeks of treatment were compared.The adverse reactions were counted in the two groups during treatment,and the recurrence of cough in the two groups within 3 months after the end of medication was observed.Results After 2 weeks of treatment,the efficacy in traditional Chinese medicine group was significantly higher than that in control group(P<0.05).The scores of TCM symptoms and levels of IL-5,IL-8,IL-10 and TNF-α in the two groups were reduced compared with those before treatment,and the scores and levels were lower in traditional Chinese medicine group than those in control group(P<0.05).Within 2 weeks of treatment,the total incidence rate of adverse reactions in traditional Chinese medicine group was lower compared with that in control group(P<0.05).There was no statistical difference in the recurrence rate between the two groups within 3 months after the end of medication(P>0.05).Conclusion Modified Xiaochaihu decoction based on time rhythm has a significant clinical efficacy in the treatment of CVA in children,and it can effectively reduce the airway in-flammation level,and it has small adverse reactions during treatment.
Time rhythmXiaochaihu decoctionChildrenCough variant asthmaAirway inflammation
万方数据
维普
