Effects of self-made Xiaoke ointment combined with insulin on negative conversion time of ketone body and blood glucose level in diabetic ketoacidosis
Objective:To explore the effects of self-made Xiaoke ointment combined with insulin on negative conversion time of ketone body and blood glucose level in diabetic ketoacidosis.Methods:A total of 60 patients with diabetic ketoacidosis treated in the hospital were enrolled between March 2020 and December 2023.The patients were put into the computer system and ran-domly ranked.According to lottery method,patients were divided into control group(routine western medicine insulin)and ob-servation group(self-made Xiaoke ointment+insulin),30 cases in each group.The clinical curative effect,disease control,scores of TCM syndromes,blood glucose level,inflammatory factors and complications in the two groups were observed.Results:The response rate of treatment in observation group was higher than that in control group(93.33%vs73.33%,P<0.05).The time of disease control indexes were shorter in observation group than control group(P<0.05).After treatment,scores of TCM syndromes(listlessness,limbs weakness,chest tightness and shortness of breath,dry mouth and thirst),24h mean blood glucose(24hMBG),mean amplitude of glycemic excursion(MAGE),largest amplitude of glycemic excursion(LAGE),levels of inter-leukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(CRP)were lower in observation group than control group(P<0.05).The incidence of complications in observation group was lower than that in control group(3.33%vs 20.00%,P<0.05).Conclusion:The curative effect of self-made Xiaoke ointment combined with insulin is good in pa-tients with diabetic ketoacidosis,which can shorten negative conversion time of ketone body,improve main symptoms,blood glu-cose,inflammatory factors and reduce the incidence of complications.
Xiaoke ointmentInsulinDiabetic ketoacidosisNegative conversion time of ketone bodyBlood glucose level
万方数据
维普
