Based on the expression of MyD88,ATF2 and NF-κB proteins in gastric mucosa,the mechanism of Huazujiadu decoction in the treatment of chronic atrophic gastritis was analyzed
Objective Based on the expression of myeloid differentiation factor 88(MyD88),activated replicator 2 antibody(ATF2)and nuclear factor-KB(NF-κB)protein in gastric mucosa,the mechanism of Huozhuojidofang in the treatment of chro-nic atrophic gastritis(CAG)was analyzed.Methods A total of 120 patients with CAG admitted to Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine from January 2021 to May 2023 were divided into the group A and the group B by ran-dom number table method,60 cases in each group.The group A was given triple therapy of Helicobacter pylori eradication,and the group B was given addition and subtraction of Huazujiedu prescription on the basis of the group A.Both groups were treated for 2 weeks.The clinical efficacy after 2 weeks of treatment.Score of castroscopic mucosal sign,fibroblast growth factor 23(FGF-23),interleukin-32(IL-32),calcitonin gene-related peptide(CGRP),human epidermal growth factor(EGF),gastric muco-sa MyD88,ATF2,NF-κB protein expression before and after 2 weeks of treatment,and adverse reactions during treatment of the two groups were compared.Results The rate of total effective in the group B after 2 weeks of treatment was higher than the group A(88.33%vs 71.67%,P<0.05).The scores of gastroscopy mucosal signs after 2 weeks of treatment were lower than before treatment,and compared with the group A,the group B was lower(P<0.05).The levels of serum FGF-23,IL-32 and EGF in two groups after 2 weeks of treatment were lower than before treatment,and compared with the group A,the group B was lower;the levels of serum CGRP in both groups after 2 weeks of treatment was higher than before treatment,and compared with the group A,the group B was higher(P<0.05).The expressions of MyD88,ATF2 and NF-κB protein in gastric mucosa of two groups af-ter 2 weeks of treatment were lower than before treatment,and compared with the group A,the group B were lower(P<0.05).there was no statistical significance of the incidence of adverse reactions during treatment between the group B and the group A(5.00%vs 11.67%,P>0.05).Conclusion Huazujiedu decoction could effectively reduce the gastric mucosal inflammatory re-action and the degree of gastric mucosal injury in patients with CAG.Analysis of the mechanism might be related to the regulation of the expression of MyD88,ATF2,NF-κB protein in gastric mucosa,which was helpful to improve the therapeutic effect,and with good safety.
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