To explore the mechanism of Gegen Qinlian Decoction and Pulsatilla Decoction in the treatment of ulcerative colitis based on inflammatoryfactors and Th17/Treg balance
Objective:To explore the clinical therapeutic effect and mechanism of Gegen Qinlian Decoction and Baitouweng Decoction in the treatment of ulcerative colitis.Method:A total of 62 patients with ulcerative colitis who were admitted to the General Hospital of the Northern Theater Command of the Chinese People's Liberation Army from January 2016 to December 2022 were selected as the study subjects.They were randomly divided into routine group(31 cases)and combined group(31 cases).The routine group was treated with routine western medicine(sulfasalazine),and the combined group was treated with Gegen Qinlian Decoction and Baitouweng Decoction on the basis of routine western medicine.The clinical efficacy,inflammatory factors,percentage of Th17 and Treg cells,intestinal barrier function,immune function,modified Mayo score(Mayo score),UC endo-scopic severity index(UCEIS score)and adverse reactions were compared between the two groups.Results:The total clinical ef-fective rate of the combined group was higher than that of the conventional group(P<0.05).After treatment,the levels of inter-leukin-6(IL-6)and IL-17 in the two groups decreased,and the level of IL-10 increased,and the levels of the above inflam-matory factors in the combined group were better than those in the conventional group(P<0.05).After treatment,the percenta-ges of Th17 cells and Th17/Treg cells in the two groups decreased,while the percentage of Treg cells increased,and the per-centages of Th17 cells,Treg cells and Th17/Treg cells in the combined group were better than those in the conventional group(P<0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the two groups increased,and the above im-mune function indexes in the combined group were higher than those in the conventional group(P<0.05).After treatment,the levels of diamine oxidase(DAO)activity,D-lactic acid(LA),endotoxin(ET)and intestinal fatty acid binding protein(i-FABP)in the two groups decreased,and the above intestinal barrier function indexes in the combined group were lower than those in the conventional group(P<0.05).After treatment,the Mayo score and UCEIS score of the two groups decreased,and the a-bove scores of the combined group were lower than those of the conventional group(P<0.05).There was no significant differ-ence in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion:The clinical effect of Gegen Qinlian Decoction combined with Baitouweng Decoction in the treatment of ulcerative colitis is obvious.It can regulate im-mune function and improve the clinical symptoms and intestinal barrier function of ulcerative colitis.Its mechanism may be related to the inhibition of the expression of inflammatory response and the correction of Th17/Treg balance.
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