首页|耳穴贴压联合电针治疗膝骨性关节炎的作用机制研究

耳穴贴压联合电针治疗膝骨性关节炎的作用机制研究

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目的:研究耳穴贴压联合电针对治疗膝骨性关节炎(Osteoarthritis,OA)的作用机制.方法:研究将某医院骨科门诊就诊的OA患者进行了随机分组,分别分为耳穴组、试验 1 组、试验 2 组,每组各 30 例.其中耳穴组以耳穴贴压联合电针治疗.试验 1 组以足三里和阳陵泉进行针灸疗法,试验 2 组以足三里和阳陵泉进行针灸治疗的同时结合单纯耳穴贴压治疗.针灸治疗每 7 天 1 个疗程,共分为 3 个疗程.每完成 1 个疗程后即利用电子测痛仪检测患者膝关节的疼痛情况,在完成 3 个疗程后利用旷场实验和H&E染色实验来检测患者的自发活动能力和病理学改变情况.此外,通过酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay,ELISA)法对患者的膝关节积液进行检测,并对其血清中的IL-1β和 TNF-α表达水平进行分析.结果:耳穴组、试验 1 组和试验 2 组的 IL-1β 表达水平分别为25.37ng/L±4.87ng/L、46.57ng/L±7.09ng/L和 36.25ng/L±4.49ng/L(P<0.05),TNF-α的表达水平分别为 120.90ng/L±12.44ng/L、260.89ng/L±21.89ng/L和 198.55ng/L±20.31ng/L(P<0.05).结论:耳穴贴压联合电针治疗相较于针灸治疗膝骨性关节炎的疗效更为确切,能有效改善膝关节运动功能以及降低关节滑液炎性指标IL-1β、TNF-α的表达.
Mechanism of different acupoints combined with acupuncture and moxibustion and auricular point sticking and pressing combined with electroacupuncture in the treatment of knee osteoarthritis
Objective Study the mechanism of ear acupoint pressing combined with electroacupuncture in the treatment of knee osteoarthritis(OA).Methods Ninety patients with osteoarthritis were randomly divided into a control group,experimental group 1,and experimental group 2,with 30 cases in each group,from the outpatient departments of Traditional Chinese Medicine and Orthopedics at the 90th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army.The ear acu-point group treated with ear acupoint pressing combined with electroacupuncture.Group 1 was treated with acupuncture and moxi-bustion at Zusanli and Yanglingquan,and group 2 was treated with acupuncture and moxibustion in combination with Zusanli and Shenshu.Acupuncture and moxibustion treatment is a course of treatment every 7 days,which is divided into 3 courses.After each course of treatment,electronic pain gauges are used to detect the patient's knee joint pain.After completing three courses,open field experiments and H&E staining experiments are used to detect the patient's spontaneous activity ability and pathological chan-ges.In addition,the knee joint effusion of patients was detected by enzyme-linked immunosorbent assay(ELISA)and IL-1 in their serum was measured β And TNF-α Analyze the expression level.Results The IL-1 in Ear Acupoint Group,Experiment 1 Group,and Experiment 2 Group β The expression levels were 25.37ng/L±4.87ng/L,46.57ng/L±7.09ng/L,and 36.25ng/L±4.49ng/L,respectively(P<0.05),indicating TNF-α The expression levels were 120.90ng/L±12.44ng/L,260.89ng/L±21.89ng/L,and 198.55ng/L±20.31ng/L,respectively(P<0.05).Conclusion Ear point sticking and pressing combined with electroacupuncture is more effective than acupuncture and moxibustion in treating knee osteoarthritis,which can ef-fectively improve the movement function of the knee joint and reduce the expression of inflammatory indicators IL-1β and TNF-α of synovial fluid.

Knee osteoarthritisIL-1 βTNF-αAcupuncture and moxibustionEar acupoint pressing

罗芳芳、薛维婳、黄赛菊、许丽梅、高松、林楚镇、林木南

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中国人民解放军联勤保障部队第九〇〇医院中医科,福建 福州 350025

膝骨性关节炎 IL-1β TNF-α 针灸 耳穴贴压

福建中医药大学校管科研课题

XB2021184

2024

四川中医
四川省中医药学会,四川省中西医结合学会,四川省针灸学会,四川省中医药科学院

四川中医

CSTPCD
影响因子:0.522
ISSN:1000-3649
年,卷(期):2024.42(9)
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