Mechanism of different acupoints combined with acupuncture and moxibustion and auricular point sticking and pressing combined with electroacupuncture in the treatment of knee osteoarthritis
Objective Study the mechanism of ear acupoint pressing combined with electroacupuncture in the treatment of knee osteoarthritis(OA).Methods Ninety patients with osteoarthritis were randomly divided into a control group,experimental group 1,and experimental group 2,with 30 cases in each group,from the outpatient departments of Traditional Chinese Medicine and Orthopedics at the 90th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army.The ear acu-point group treated with ear acupoint pressing combined with electroacupuncture.Group 1 was treated with acupuncture and moxi-bustion at Zusanli and Yanglingquan,and group 2 was treated with acupuncture and moxibustion in combination with Zusanli and Shenshu.Acupuncture and moxibustion treatment is a course of treatment every 7 days,which is divided into 3 courses.After each course of treatment,electronic pain gauges are used to detect the patient's knee joint pain.After completing three courses,open field experiments and H&E staining experiments are used to detect the patient's spontaneous activity ability and pathological chan-ges.In addition,the knee joint effusion of patients was detected by enzyme-linked immunosorbent assay(ELISA)and IL-1 in their serum was measured β And TNF-α Analyze the expression level.Results The IL-1 in Ear Acupoint Group,Experiment 1 Group,and Experiment 2 Group β The expression levels were 25.37ng/L±4.87ng/L,46.57ng/L±7.09ng/L,and 36.25ng/L±4.49ng/L,respectively(P<0.05),indicating TNF-α The expression levels were 120.90ng/L±12.44ng/L,260.89ng/L±21.89ng/L,and 198.55ng/L±20.31ng/L,respectively(P<0.05).Conclusion Ear point sticking and pressing combined with electroacupuncture is more effective than acupuncture and moxibustion in treating knee osteoarthritis,which can ef-fectively improve the movement function of the knee joint and reduce the expression of inflammatory indicators IL-1β and TNF-α of synovial fluid.
Knee osteoarthritisIL-1 βTNF-αAcupuncture and moxibustionEar acupoint pressing