Exploration of traditional Chinese medicine in patients with gastric cancer and peripheral blood CXCR4,IL-6/STAT3pathway
Objective:To explore the relationship between TCM syndrome differentiation and peripheral blood chemokine recep-tor(CXCR)4,interleukin(IL)-6/signal transduction transcription-activating factor(STAT)3pathways in patients with gastric cancer.Methods:A total of 124patients with gastric cancer admitted to our hospital from May 2022to May 2023were included for a-nalysis,and TCM differentiation of gastric cancer patients was performed according to clinical symptoms and pulse.The immune function[CD3+,CD4+,CD4+/CD8+],peripheral blood CXCR4,IL-6/STAT3pathway expression and prognosis of patients with different syndrome types of gastric cancer were compared.Results:The 124cases of gastric cancer mainly included 5syndrome differ-entiation types,including 33cases(26.61％)of liver-Qi-invaded stomach syndrome,24cases(19.35％)of spleen-stomach defi-ciency cold syndrome,29cases(23.39％)of stomach heat injury Yin syndrome,21cases(16.94％)of qi stagnation and blood sta-sis syndrome,17cases(13.71％)of qi blood deficiency syndrome.The expression of CXCR4,IL-6and STAT3mRNA in peripheral blood of gastric cancer patients with 5types of syndrome differentiation showed that Qi-blood-stasis syndrome and Qi-blood-deficien-cy syndrome were higher than those of the other 3types(P＜0.05),and there was no statistical significance between Qi-blood-stasis syndrome and Qi-blood-deficiency syndrome(P＞0.05).The immune function of gastric cancer patients with 5types of syndrome differentiation showed that CD3+,CD4,CD4+/CD8+of Qi-blood stasis syndrome and Qi-blood deficiency syndrome were lower than those of other 3types(P＜0.05),and Qi-blood deficiency syndrome was lower than Qi-blood stasis syndrome(P＜0.05).Af-ter 1year of follow-up,the survival rate of Qi-blood-stasis syndrome and Qi-blood-deficiency syndrome was lower than that of other 3syndrome types(P＜0.05),and there was no statistical significance between Qi-blood-stasis syndrome and Qi-blood-deficiency syndrome(P＞0.05).Conclusion:The common TCM syndrome differentiation types in patients with gastric cancer mainly include liver-qi attack on stomach syndrome,spleen-stomach deficiency cold syndrome,stomach heat injury to Yin syndrome,qi stagnation and blood stasis syndrome,and qi and blood deficiency syndrome,and there are differences in peripheral blood CXCR41evel and IL-6/STAT3pathway expression among patients with different syndrome differentiation types.
万方数据
维普
