四川中医2024，Vol.42Issue(11) ：17-20.

成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系

The characteristics of TCM syndromes in adult patients with bronchial asthma attack and their relationship with miR-155-5p andTreg/Th17cell balance

魏挺 彭宇 姚纲
四川中医2024，Vol.42Issue(11) ：17-20.
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成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系

The characteristics of TCM syndromes in adult patients with bronchial asthma attack and their relationship with miR-155-5p andTreg/Th17cell balance

魏挺 1彭宇 2姚纲3
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作者信息

  • 1. 西安交通大学医院内科,陕西西安 710049
  • 2. 西安交通大学第一附属医院康复科,陕西西安 710061
  • 3. 宝鸡市凤翔区中医医院内四科,陕西宝鸡 721400
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摘要

目的:探讨成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系.方法:选择2022年3月～2024年2月在我院及我院上级医联体医院就诊的成人支气管哮喘发作期患者116例作为研究对象.收集患者一般资料、miR-155-5p mRNA、Treg/Th17及相关细胞因子[白细胞介素(IL)-17、IL-23]指标,同时对患者进行中医辨证分型,比较不同中医证型患者一般资料、miR-155-5p、Treg/Th17、IL-17、IL-23水平.结果:116例成人支气管哮喘发作期患者中医辨证为热哮、风哮、冷哮、虚哮,占比分别为34.48％(40/116),31.90％(37/116),22.41％(26/116),11.21％(13/116).其中虚哮者年龄均高于风哮、热哮、冷哮者(P＜0.05),其余证型年龄无差异(P＞0.05).不同中医证型患者病程、肺功能指标无差异(P＞0.05).不同中医证型患者miR-155-5p mRNA、Treg/Th17、IL-17、IL-23水平比较有差异(P＜0.05),且风哮＞冷哮＞热哮＞虚哮(P＜0.05).结论:成人支气管哮喘发作期以热哮、风哮为主,风哮患者miR-155-5p水平升高,Treg/Th17失衡,两者可能作为成人支气管哮喘发作期证型客观化的指标之一.

Abstract

Objective:To explore the characteristics of TCM syndromes in adult patients with bronchial asthma and its relation-ship with miR-155-5p and Treg/Th17cell balance.Methods:A total of 116adult patients with bronchial asthma who were treated in our hospital and our superior medical consortium hospital from March 2022to February 2024were selected as subjects.The general da-ta of patients,miR-155-5p mRNA,Treg/Th17and related cytokines[interleukin(IL)-17,IL-23]were collected.At the same time,the patients were classified according to TCM syndrome differentiation,and the general data,miR-155-5p,Treg/Th17,IL-17and IL-23levels of patients with different TCM syndromes were compared.Results:The TCM syndromes of 116adult patients with bronchial asthma attack were heat asthma,wind asthma,cold asthma and deficiency asthma,accounting for 34.48％(40/116),31.90％(37/116),22.41％(26/116)and 11.21％(13/116),respectively.Among them,the age of deficiency asthma was higher than that of wind asthma,heat asthma and cold asthma(P＜0.05).There was no difference in the course of disease and pul-monary function indexes between patients with different TCM syndromes(P＞0.05).There were differences in the levels of miR-155-5p mRNA,Treg/Th17,IL-17and IL-23in patients with different TCM syndromes(P cold asthma＞heat asthma＞deficiency asthma)(P＜0.05).Conclusion:The attack stage of bronchial asthma in adults is dominated by heat asthma and wind asthma.The level of miR-155-5p in patients with wind asthma is increased,and Treg/Th17is imbalanced.Both of them may be used as one of the objective indicators of syndrome type in the attack stage of bronchial asthma in adults.

关键词

支气管哮喘/发作期/中医证型特点/miR-155-5p/Treg/Th17细胞平衡

Key words

Bronchial asthma/Attack period/Characteristics of TCM syndromes/miR-155-5p/Treg/Th17cell balance

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出版年

2024
四川中医
四川省中医药学会，四川省中西医结合学会，四川省针灸学会，四川省中医药科学院

四川中医

CSTPCD
影响因子：0.522
ISSN：1000-3649
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