The characteristics of TCM syndromes in adult patients with bronchial asthma attack and their relationship with miR-155-5p andTreg/Th17cell balance
Objective:To explore the characteristics of TCM syndromes in adult patients with bronchial asthma and its relation-ship with miR-155-5p and Treg/Th17cell balance.Methods:A total of 116adult patients with bronchial asthma who were treated in our hospital and our superior medical consortium hospital from March 2022to February 2024were selected as subjects.The general da-ta of patients,miR-155-5p mRNA,Treg/Th17and related cytokines[interleukin(IL)-17,IL-23]were collected.At the same time,the patients were classified according to TCM syndrome differentiation,and the general data,miR-155-5p,Treg/Th17,IL-17and IL-23levels of patients with different TCM syndromes were compared.Results:The TCM syndromes of 116adult patients with bronchial asthma attack were heat asthma,wind asthma,cold asthma and deficiency asthma,accounting for 34.48％(40/116),31.90％(37/116),22.41％(26/116)and 11.21％(13/116),respectively.Among them,the age of deficiency asthma was higher than that of wind asthma,heat asthma and cold asthma(P＜0.05).There was no difference in the course of disease and pul-monary function indexes between patients with different TCM syndromes(P＞0.05).There were differences in the levels of miR-155-5p mRNA,Treg/Th17,IL-17and IL-23in patients with different TCM syndromes(P cold asthma＞heat asthma＞deficiency asthma)(P＜0.05).Conclusion:The attack stage of bronchial asthma in adults is dominated by heat asthma and wind asthma.The level of miR-155-5p in patients with wind asthma is increased,and Treg/Th17is imbalanced.Both of them may be used as one of the objective indicators of syndrome type in the attack stage of bronchial asthma in adults.
Bronchial asthmaAttack periodCharacteristics of TCM syndromesmiR-155-5pTreg/Th17cell balance
万方数据
维普
