The curative effect of Linggui Zhugan Decoction combined with moxibustion therapy on patients with chronic heart failure and the effects of miR-125b-5p and Th17/Treg
Objective:To explore the efficacy of Linggui Zhugan Decoction combined with moxibustion therapy on patients with chronic heart failure and the effects of miR-125b-5p and peripheral blood helper T lymphocyte 17(Th17)/regulatory T lympho-cyte(Treg).Methods:A total of 186patients with chronic heart failure(CHF)who were treated in our hospital from May 2021to May 2023were randomly divided into control group(n=93)and combined group(n=93).The control group was given convention-al western medicine intervention+moxibustion therapy,and the combined group was given conventional western medicine interven-tion+moxibustion therapy+Linggui Zhugan Decoction.The two groups were continuously intervened for 4weeks.The clinical effica-cy,TCM syndrome scores,cardiac function indexes,6-minute walking distance changes,miR-125b-5p and Th17/Treg levels be-fore and after 4weeks of treatment were statistically analyzed.Results:After treatment,the efficacy levels of the two groups were dif-ferent(P＜0.05),and the effective rate of the combined group was higher than that of the control group[79.57％vs 66.66％](P＜0.05).There was no difference in TCM syndrome score,cardiac function index,6-minute walking distance,miR-125b-5p and Th17/Treg between the two groups before treatment(P＞0.05).After treatment,the scores of main symptoms and secondary symp-toms of TCM syndromes,left ventricular end-diastolic diameter(LVED),miR-125b-5p and Th17/Treg were down-regulated,left ventricular ejection fraction(LVEF)and 6-minute walking distance were increased in both groups,and the combined group was better(P＜0.05).Conclusion:Linggui Zhugan Decoction combined with moxibustion therapy can effectively treat CHF,improve clinical symptoms,and reduce the levels of miR-125b-5p and Th17/Treg,thereby improving cardiac function.
Chronic heart failureMoxibustionLinggui Zhugan DecoctionmiR-125b-5pT helper lymphocyte 17Regula-tory T lymphocytes
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维普
