目的:观察小柴胡汤合葛根芩连汤加减治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期肺脾气虚兼湿热证的临床疗效.方法:对2021年7月～2022年3月的COPD稳定期肺脾气虚兼湿热证患者78例行回顾性分析,依据治疗差异分为对照组39例(予常规西药治疗)和试验组39例(予常规西药+小柴胡汤合葛根芩连汤加减治疗).对比两组临床疗效、证候积分、肺功能[第1秒用力呼气容积(Force the expiratory volume for the first second,FEV1)、第 1 秒用力呼气容积/用力肺活量(Force the expiratory volume for the first second/Forced Vital Capacity,FEV1/FVC)]、6min 步行距离(6minute walking distance,6MWD)、慢阻肺生活质量量表(COPD Assessment Test,CAT)及安全性.结果:对照组、试验组总疗效率分别为74.36％、92.31％,试验组总疗效率更高(P＜0.05).两组治疗后,证候总积分均下降,但试验组证候总积分下降幅度更大(P＜0.05).两组治疗后FEV1、FEV1/FVC值均上升,且试验组比对照组高(P＜0.05).两组治疗后6MWD的距离均延长,且试验组明显长于对照组(P＜0.05).两组治疗后CAT评分(包括咳嗽、咳痰、胸闷、睡眠、情绪、精力评分)均降低,且试验组明显低于对照组(P＜0.05).治疗期间,对照组不良反应总发生率为2.56％(1/39),试验组不良反应总发生率为5.12％(2/39),两组不良反应总发生率相比较,差异无统计学意义(P＞0.05).结论:小柴胡汤合葛根芩连汤加减治疗可改善COPD稳定期肺脾气虚兼湿热证的患者生活质量、肺功能,提高临床疗效.
Clinical observation of Xiaochaihu Decoction combined with Gegen Qinlian Decoction in treatment of chronic obstruc-tive pulmonary disease in stable stage
Objective:To observe the clinical effect of Xiaochaihu Decoction combined with Gegenqinlian Decoction in the treat-ment of Chronic obstructive pulmonary disease(COPD)combined with dampness-heat syndrome.Methods:78patients with lung Qi deficiency and damp-heat syndrome in stable COPD from July 2021to March 2022were retrospectively analyzed,and were divided in-to 39cases in control group(treated with conventional western medicine)and 39cases in experimental group(treated with conven-tional western medicine plus Xiaochaihu decoction and Gegen Qinlian decoction)according to treatment differences.The clinical effi-cacy,syndrome score,lung function[Force the expiratory volume for the first second(FEV1),Force the expiratory volume for the first second/Forced Vital Capacity(FEV1/FVC)],6minute walking distance(6MWD)and COPD Assessment Test(CAT)and safety were compared between the two groups.Results:The total curative effect rate of control group and experimental group were 74.36％and 92.31％,respectively,and the total curative effect rate of experimental group was higher(P＜0.05).After treatment,the total score of syndrome decreased in the two groups,but the decrease of total score in experimental group was greater(P＜0.05).The FEV1 and FEV1/FVC values of the two groups increased after treatment,and the experimental group was higher than the control group(P＜0.05).The distance of 6MWD in the two groups was extended after treatment,and the experimental group was signifi-cantly longer than the control group(P＜0.05).After treatment,CAT scores(including cough,phlegm,chest tightness,sleep,mood and energy scores)were decreased in the two groups,and the test group was significantly lower than the control group(P＜0.05).During treatment,the total incidence of adverse reactions was 2.56％(1/39)in the control group and 5.12％(2/39)in the experimental group.There was no statistical significance in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Modified Xiaochaihu Decoction and Gegen Qinlian Decoction can improve the quality of life,lung function and clinical efficacy of patients with stable COPD of lung-spleen qi deficiency and damp-heat syndrome.
Xiaochaihu Decoction combined with Gegen Qinlian decoctionChronic obstructive pulmonary diseaseStable peri-odLung and spleen Qi deficiency combined with dampness-heat syndrome
万方数据
维普
