Effect of Shaoyao Gancao decoction combined with modified Sihuang powder on liver cancer pain,pain mediators and inflammatory factors
Objective:To analyze the curative effect of Shaoyaogancao decoction combined with modified Sihuang powder on cancer pain of liver cancer,the influence of pain mediators and inflammatory factors.Methods:Sixty-eight patients with liver cancer pain admitted to our hospital from January 2022to December 2023were retrospectively selected as the study objects,and were divided into observation group(n=36)and control group(n=32)according to different treatment plans.The control group received con-ventional analgesic treatment,and the observation group received conventional analgesic treatment plus Shaoyao Gancao decoction combined with Jiawei Sihuang powder external treatment,both groups were treated for 4weeks.The therapeutic effects and pain medi-ators of the two groups were compared[βendorphin(β-EP),prostaglandin E2(PGE2),Substance P(SP)],inflammatory fac-tors[interleukin-6,IL-1 β,tumor necrosis factor α(TNF-α)],visual analogue scale(VAS),QOL-LC score and adverse e-vents.Results:The treatment effect of observation group was better than that of control group(P＜0.05).After treatment,the β-EP level in observation group was higher than that in control group(P＜0.05),and the levels of PGE2,SP,IL-6,IL-1 β and TNF-α were lower than those in control group(P＜0.05).VAS,QOL-LC score in observation group were better than the control group(P＜0.05).There was no statistical significance in the incidence of adverse events between the two groups(P＞0.05).Conclusion:Shaoyaogancao decoction combined with modified Sihuang powder has a good effect on improving the pain of liver cancer,which helps to improve the levels of pain mediators and inflammatory factors in patients,so as to reduce the degree of pain,improve the quality of life,and have good safety.
Liver cancer painShaoyao Gancao decoctionModified Sihuang powderPain mediatorsInflammatory factors
万方数据
维普
