Curative effectof Zishen Qingxin Shugan Decoction combined with acupoint application and MHT on patients with per-imenopausal insomnia
Objective:To explore the curative effect of Zishen Qingxin Shugan Decoction combined with acupoint application and menopausal hormone therapy(MHT)on patients with perimenopausal insomnia(PMI).Methods:A total of 102patients with PMI were retrospectively enrolled as the research objects between January 2022and December 2023.According to treatment methods,they were divided into observation group(n=34),control group 1(n=34)and control group 2(n=34).The control group l was treated with MHT,control group 2was treated with Zishen Qingxin Shugan Decoction combined with acupoint application,observation group was treated with Zishen Qingxin Shugan Decoction,acupoint application,and MHT.The clinical curative effect,scores of TCM syndromes,cortisol,glucose-lipid metabolism indexes[fasting plasma glucose(FPG),triglyceride(TG),low-density lipo-protein cholesterol(LDL-C)],sex hormones[follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH)]and psychological state[self-rating anxiety scale(SAS),self-rating depression scale(SDS)]were compared before treat-ment and 1month after treatment between the three groups.Results:After 4weeks of treatment,the total response rate of observation group was better than that of control group 1and control group 2(P<0.05),scores of TCM symptoms(insomnia,difficulty in falling asleep,palpitation and dreaminess)in observation group were lower than those in control group 1and control group 2(P<0.05),the cortisol level was higher than that of control group 1and control group 2(P<0.05),levels of FPG,TG and LDL-C were lower than those in control group 1and control group 2(P<0.05).After 6months of follow-up,FSH and LH levels in observation group were low-er than those in control group 1and control group 2,and E2levels were higher than those in control group 1and control group 2(P<0.05).After 4weeks of treatment,SAS and SDS scores in observation group were lower than those in control group 1and control group 2(P<0.05).Conclusion:Zishen Qingxin Shugan Decoction combined with acupoint application and MHT can effectively relieve clini-cal symptoms,improve cortisol,glucose-lipid metabolism,sex hormones and psychological state in PMI patients.