The efficacy of Huayu Wenjing Decoction combined with Guizhi Fuling Capsule in the treatment of endometriosis of cold coagulation and blood stasis type and its effect on serum MMP-3,TGF-β,PGF2α and EMAb levels
Objective:To observe the curative effect of Huayu Wenjing Decoction combined with Guizhi Fuling Glue in the treatment of endometriosis of cold coagulation and blood stasis type and its effect on the levels of serum matrix metalloproteinase-3(MMP-3),transforming growth factor-β(TGF-β),prostaglandin F2α(PGF2α)and anti-endometrial antibody(EMAb).Methods:The clinical data of 78patients with endometriosis of cold coagulation and blood stasis type admitted to our hospital from Ju-ly 2021to July 2023were retrospectively analyzed.The patients were divided into reference group(n=37)and observation group(n=41)according to different treatment schemes.The reference group was treated with conventional western medicine,and the obser-vation group was treated with Huayu Wenjing Decoction combined with Guizhi Fuling Capsule on this basis.The pain,quality of life,MMP-3,TGF-β,PGF2α and EMAb levels before and after treatment were compared between the two groups,and the incidence of adverse reactions during treatment was recorded.Results:After treatment,the total effective rate of the reference group was lower than that of the observation group(P＜0.05).Compared with the reference group,the scores of Jane's McGill pain questionnaire[pain rating index(PRI),visual analogue scale(VAS),present pain intensity(PPI)]and endometriosis quality of life scale(EHP-5)in the observation group were significantly lower after treatment(P＜0.05).Compared with the reference group,the lev-els of serum MMP-3,TGF-β,PGF2α and EMAb in the observation group were significantly lower after treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the reference group and the observation group(P＞0.05).Conclusion:Huayu Wenjing Decoction combined with Guizhi Fuling Capsule has a significant effect on patients with endome-triosis of cold coagulation and blood stasis type.It can relieve pain,improve the quality of life of patients,regulate the levels of ser-um MMP-3,TGF-β,PGF2α and EMAb,and has good safety.
万方数据
维普
