Clinical study on the treatment of first-episode young depression patients with Xingnao Kaiqiao acupuncture combined with sertraline based on diffusion tensor imaging
Objective:To explore the efficacy and safety of acupuncture combined with sertraline in the treatment of depression based on the changes in the microstructure of white matter fiber tracts using diffusion tensor imaging(DTI)technology.Methods:Sixty first-episode young patients with depression,who were treated with sertraline for the first time,were randomly divided into an acupuncture group and a drug group,with 30cases in each group.The drug group was treated with oral sertraline alone,50mg per day,once a day.The acupuncture group was treated with Xingnao Kaiqiao acupuncture once a day for 4weeks on the basis of the drug group.Another 30healthy subjects were taken as the healthy group.Before and after 4weeks of treatment,the effect and safety of the two groups were evaluated using the Hamilton Depression Scale(HAMD-17).At the same time,the fractional anisotropy(FA)values of the brain regions of the patients were measured using DTI technology before and after 4weeks of treatment.Results:After 4weeks of treatment,the HAMD-17 scores of the two groups were decreased(P＜0.05),and the HAMD-17scores of the acupunc-ture group were lower than those of the drug group(P＜0.05).Compared with the healthy subjects,the FA values of 6brain regions of depression showed significant changes,respectively,the splenium of corpus callosum,the left cingulate tract,the left cortical spi-nal cord tract,the right thalamic radiation,and the temporal part of the bilateral superior longitudinal tract.Before treatment,there was no significant difference in FA values of 6brain regions between the two groups of patients with depression(P＞0.05).After treatment,the FA values of splenium of corpus callosum,left cingulate tract,left cortical spinal cord tract,right thalamic radiation and bilateral temporal part of superior longitudinal tract in the acupuncture-drug group were higher than those in the drug group(P＜0.05).Conclusion:Acupuncture can repair the morphological structure of white matter fiber tracts in some brain regions to a cer-tain extent,and assisting sertraline in the treatment of depression is conducive to enhancing the curative effect.
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