Correlation between gene mutation of essential thrombocythemia and TCM syndrome type and thrombus risk
Objective:To explore the correlation between gene mutation of essential thrombocythemia and traditional Chinese medicine(TCM)syndrome type and thrombus risk.Methods:The clinical data of 78patients with essential thrombocythemia admitted to Langfang Hospital of Traditional Chinese Medicine from October 2016to October 2020were retrospectively selected as the study ob-jects,and the patients were divided into CALR group,JAK2group and negative group according to their driver gene mutation types.The clinical data,TCM syndrome type,serological index,thrombus risk degree and prognosis grade of the three groups were com-pared.Results:Among 78patients with essential platelet,22patients with CALR gene mutation,accounting for 28.21%;there were 40patients with JAK2gene mutation,accounting for 51.28%.Three Yin type 12cases,accounting for 15.38%;4patients with MPL gene mutation,accounting for 5.13%.The TCM syndromes of the three groups are mainly qi stagnation and blood stasis,followed by qi deficiency and blood stasis and kidney deficiency and blood stasis.There was no significant difference in TCM syndrome types a-mong the three groups(P＞0.05).The white blood cell count and hemoglobin level of the three groups were compared,and the differ-ence was statistically significant(P＜0.05).There was no significant difference in platelet count and fibrinogen level among the three groups(P＞0.05).The risk of thrombosis in the three groups was compared,and the difference was statistically significant(P＜0.05).The prognosis grading of the three groups was compared,and the difference was statistically significant(P＜0.05).Conclusion:There is a certain correlation between the gene mutation of primary thrombocytosis and the risk of thrombosis,and the risk of thrombosis and prognosis of patients can be predicted according to different genotypes.
万方数据
维普
