Relationship between TCM syndrome type and serum miR-33a,inflammatory markers and prognosis in patients with type 2diabetes mellitus complicated with stable angina pectoris
Objective:To explore the relationship between TCM syndrome type and serum miR-33a,inflammatory markers and prognosis in T2DM-SAP patients.Methods:A total of 119T2DM-SAP patients admitted to our hospital from November 2021to No-vember 2022were included.TCM syndrome differentiation of T2DM-SAP patients was performed according to clinical symptoms and pulse,and relevant clinical data of patients with different syndrome types were retrospectively collected.To compare the expression of serum miR-33a,levels of inflammatory markers[procalcitonin(PCT),homocysteine(Hcy)and serum hypersensitive C-reactive protein(hs-CRP)]and prognosis of patients with different syndromes of T2DM-SAP[moderate to severe cardiovascular adverse e-vents(all-cause death,Myocardial infarction readmission or stroke recurrence),mild(transient ischemic attack and angina pectoris readmission)].Results:Among the 119T2DM-SAP patients,there were four types of clinical distribution,including 38cases(31.93％)of qi deficiency and blood stasis,34cases(28.57％)of phlegm-stasis interformation,25cases(21.01％)of qi deficiency and 22cases(18.49％)of yin-yang deficiency.The serum miR-33a expression,PCT,Hcy and hs-CRP levels of the four syndrome types were higher than those of the other two syndrome types(P＜0.05),and the syndrome of phlegm and blood stasis was higher than that of Qi deficiency and blood stasis(P＜0.05).Compared with the prognosis,the total incidence of adverse cardiovascular events in the syndrome of phlegm-stasis interjunction was higher than that of the other three types(P＜0.05),but there was no statistical differ-ence between the syndrome of Qi-yin deficiency,Qi-blood stasis syndrome and yin-yang deficiency syndrome(P＞0.05).Conclu-sion:Common TCM syndrome types in T2DM-SAP patients include qi deficiency and blood stasis syndrome,phlegm-stasis interjunc-tion syndrome,qi Yin deficiency syndrome and Yin and Yang deficiency syndrome,and there are differences in prognosis,serum miR-33a expression and inflammatory marker levels among patients with different syndrome types.
Type 2diabetesInflammatory markersStable angina pectorisTCM syndrome typeSerum microRNA-33a
万方数据
维普
