Analysis of vascular endothelial function,Th17/Treg levels and prognosis of patients with acute coronary syndrome in different Chinese medicine certificates
Objective To analyze the vascular endothelial function,helper T-cell 17(Th17)/regulatory T-cell(Treg)levels and prognosis of patients with acute coronary syndrome(ACS)in different Chinese medicine certificates.Methods The 114ACS pa-tients who received treatment in our hospital from January 2022to March 2023were included,and were categorized into qi deficiency and blood stasis,qi and yin deficiency,and phlegm and blood stasis mutual obstruction according to different Chinese medicine evi-dence types.Another 33medical examiners who underwent health checkups during the same period were included as the control group,and endothelial function[vascular endothelial growth factor(VEGF),endothelin-1(ET-1)],Th17ratio,Treg ratio,and Th17/Treg ratio were detected and compared between patients with different Chinese medicine certificates of ACS,and the control group.The ACS patients were followed up for one year,and the major adverse cardiovascular events(MACE)of ACS patients with different TCM certificates were statistically compared.Results Among the 114ACS patients,there were 31cases of qi deficiency and blood stasis,34cases of qi and yin deficiency,and 49cases of phlegm and stasis mutual obstruction.ET-1,Th17ratio,Treg ratio and Th17/Treg were higher than those of the control group in ACS patients of all TCM evidence types,while VEGF was lower than those of the control group(P＜0.05).Compared with qi and yin deficiency and phlegm and stasis mutual obstruction,patients with qi deficiency and blood stasis had higher ET-1,Th17ratio,Treg ratio and Th17/Treg,and lower VEGF(P＜0.05).The incidence of MACE in patients with qi deficiency and blood stasis were all higher than those with qi and yin deficiency and phlegm and stasis mutual obstruction(P＜0.05).Conclusion Patients with ACS have reduced vascular endothelial function,elevated Th17/Treg levels,and more pronounced manifestations of qi deficiency and blood stasis,and patients with this syndrome have a poorer prognosis.
Chinese medicine evidenceAcute coronary syndromeVascular endothelial functionThelper cell 17/regulatory T cellsPrognosis
万方数据
维普
