Study on the correlation between TCM syndrome differentiation and soluble adhesion molecules and inflammatory fac-tors in SLE
Objective:To explore the relationship between TCM dialectical classification of systemic lupus erythematosus and sol-uble adhesion molecules and inflammatory factors.Methods:A total of 218patients with systemic lupus erythematosus who were treated in our hospital from May 2020to June 2023were selected for this study.According to the dialectical classification of traditional Chinese medicine,they could be divided into liver and kidney Yin deficiency group,spleen and kidney Yang deficiency group and heat toxicity intense group.The differences of basic data,disease activity index,serum soluble adhesion molecules and inflammatory factors among patients with different syndrome types were compared.Pearson correlation analysis was used to explore the relationship between differ-ent TCM dialectical types and serum levels of soluble adhesion molecules and inflammatory factors.Results:In 218patients,60cases of liver and kidney Yin deficiency,66cases of spleen and kidney Yang deficiency,and 92cases of heat and toxin incandescence were included.There were significant differences in SLEDAI scores among different TCM syndrome differentiation types,liver and kidney Yin deficiency grouP＜spleen and kidney Yang deficiency grouP＜heat toxicity blazing group(P＜0.05);The serum levels of soluble intercellular adhesion molecule-1(sICAM-1)and vascular endothelial cell adhesion molecule-1(sVCAM-1)in different TCM syn-drome differentiation types were significantly different,and the levels of both were liver and kidney Yin deficiency grouP＜spleen and kidney Yang deficiency grouP＜heat toxicity intense group(all P＜0.05).The expression levels of γ-interferon(IFN-γ),tumor nec-rosis factor α(TNF-α)and interleukin-10(IL-10)in serum of patients with different TCM syndrome differentiation types were dif-ferent,and the level of TNF-α in heat toxicity incandescating group was higher than that in spleen-kidney Yang deficiency group(P＜0.05).The levels of IFN-γ,TNF-α and IL-10in 2groups were higher than those in liver-kidney Yin deficiency group(P＜0.05),while the levels of IFN-γ and IL-10in heat toxicity incandescence group were not statistically significant compared with spleen-kidney Yang deficiency group(P＞0.05).Pearson correlation analysis showed that SLEDAI score of different TCM syndrome differentiation types was positively correlated with serum sICAM-1,sVCAM-1,IFN-γ,TNF-α and IL-10(P＜0.05).Conclusion:There is a certain correlation between different TCM syndrome differentiation types of systemic lupus erythematosus and soluble adhesion mole-cules and inflammatory factors.The detection of serum soluble adhesion molecules and inflammatory indicators can be used as an auxil-iary tool for TCM syndrome differentiation,which is conducive to the improvement of diagnostic value.
systemic lupus erythematosusTCM syndrome differentiation and classificationInflammatory factorsSoluble ad-hesion molecule
万方数据
维普
