Changes and clinical significance of miR-21,IL-12and T lymphocyte subsets in peripheral blood of patients with color-ectal cancer with different TCM syndrome types
Objective:To study TCM syndrome differentiation and peripheral blood microrna(miR-21),interleukin(IL)-12and T lymphocyte subsets in patients with colorectal cancer and its clinical significance.Method:The medical records of 204patients with colorectal cancer admitted to Oncology Department of our hospital from February 2020to August 2023were retrospec-tively analyzed.According to TCM syndrome types,the patients were divided into 58cases of dampness-heat syndrome,41cases of spleen deficiency qi stagnation syndrome,39cases of spleen and kidney deficiency syndrome,37cases of qi and blood deficiency syn-drome,and 29cases of internal blockage of blood stasis.To compare the levels of miR-21,IL-12and T lymphocyte subsets in periph-eral blood of colorectal cancer patients with different TCM syndrome types.Pearson correlation was used to analyze the correlation be-tween TCM syndrome types of colorectal cancer and peripheral blood miR-21,IL-12,CD3+,CD3+CD4+T.Results:There were significant differences in serum miR-21,IL-12,CD3+,CD3+CD4+T among 5types of colorectal cancer patients(P＜0.05).The se-rum levels of miR-21,CD3+,CD3+CD4+T in patients with spleen-kidney deficiency syndrome were lower than those in patients with internal blockage of stasis,deficiency of qi and blood,spleen deficiency qi stagnation syndrome,and internal dampness-heat syn-drome(P＜0.05),and the levels of IL-12were higher than those in patients with other 4types of syndrome(P＜0.05).The results of Pearson correlation analysis showed that the TCM syndrome type of colorectal cancer was positively correlated with miR-21,CD3+,CD3+CD4+T,and negatively correlated with IL-12(P＜0.05).Conclusion:Damp-heat syndrome is the highest in colorectal cancer patients,followed by spleen deficiency qi stagnation syndrome.The levels of miR-21,IL-12,CD3+,CD3+CD4+T in peripheral blood of patients with different TCM syndrome types are different,which can provide reference for TCM syndrome differentiation and disease evaluation of colorectal cancer.
万方数据
维普
