Study on correlation between TCM syndrome differentiation and serum levels of SAA,miR-146a,leptin and chemokine in rheumatoid arthritis
Objective To investigate the correlation between the syndrome differentiation of rheumatoid arthritis and the levels of serum amyloid A(SAA),microrna(miR)-146a,leptin and chemokine.Methods 240patients with rheumatoid arthritis treated in Rheumatology Department of our hospital from May 2021to May 2023were selected as the research objects.According to the TCM syn-drome differentiation standard,they were divided into 6syndrome types:cold-dampness obstruction,wind-dampness obstruction,phlegm-stasis obstruction,damp-heat obstruction,deficiency of liver and kidney and deficiency of qi and blood.Serum levels of SAA,miR-146a,leptin,chemokine and 28joint disease activity scores(DAS28)were compared in patients with rheumatoid arthritis of different TCM syndrome differentiation types,and the correlation between serum levels of SAA,miR-146a,leptin,chemokine and DAS28scores was analyzed by Spearman correlation analysis.Results The DAS28scores of patients with rheumatoid arthritis of different TCM syndrome differentiation types were successively from large to small,namely,dampness-heat obstruction group,wind-damp-ness-obstruction,cold-dampness-obstruction,phlegm-stasis obstruction,deficiency of liver and kidney syndrome,and deficiency of qi and blood syndrome.The difference among the scores of each syndrome type was statistically significant(P＜0.05).The serum lev-els of SAA,miR-146a,leptin and chemoattractant in patients with 6syndrome types were compared,and the differences were statisti-cally significant(P＜0.05).The change trend of serum SAA level was as follows:dampness-heat obstruction grouP＞wind-damp-ness obstruction syndrome＞cold-dampness obstruction syndrome＞Phlegm-stasis obstruction syndrome＞deficiency of liver and kid-ney syndrome＞deficiency of qi and blood syndrome.The change trend of miR-146a,letin and chemokine level was as follows:dampness-heat obstruction grouP＞cold-dampness obstruction syndrome＞wind-dampness obstruction syndrome＞Phlegm-stasis ob-struction syndrome＞deficiency of liver and kidney syndrome＞deficiency of qi and blood deficiency syndrome.Spearmen correlation analysis showed that serum levels of SAA,miR-146a,leptin and chemokine were positively correlated with DAS28scores(P＜0.05).Conclusion The proportion of dampness-heat obstruction in patients with rheumatoid arthritis is the highest,followed by wind-damp-ness obstruction,phlegm-stasis obstruction,deficiency of liver and kidney and cold-dampness obstruction,and finally Qi-blood defi-ciency syndrome.The serum levels of SAA,miR-146a,leptin and chemokine are related to the TCM syndrome differentiation and dis-ease activity of rheumatoid arthritis,which can be used as a reference index for TCM syndrome differentiation of damp-heat obstruction and wind-dampness obstruction.
万方数据
维普
