Effect of self-prepared Huowei Decoction combined with acupuncture on chronic atrophic gastritis and its influence on TLR4inflammatory pathway and gastric mucosal function
Objective:To analyze the effect of self-prepared Huowei Decoction combined with acupuncture on chronic atrophic gastritis and its effects on TLR4inflammatory pathway and gastric mucosal function.Methods:A total of 196patients,who underwent treatment for chronic atrophic gastritis in the hospital spanning from March 2022to February 2024,were selected and categorized into two distinct groups:an observation group comprising 99individuals and a control group consisting of 97patients,based on variations in their therapeutic approaches.Patients in both groups were given routine treatment such as smoking and alcohol prohibition,health edu-cation,etc.In the control group,patients underwent acupuncture therapy on the basis of conventional treatment,and patients in the observation group were combined with self-prepared Huowei Decoction on the basis of conventional treatment and acupuncture treat-ment.The therapeutic effects and adverse reactions were compared between the two groups.The TCM syndrome scores(epigastric dis-tending pain,qi stasis,food accumulation,gas and acid swallowing,nausea and vomiting),TLR4inflammatory pathway(IL-6,TNF-α,TLR4,NF-κB)and gastric mucosal function(gastrin,pepsinogen Ⅰ/pepsinogen Ⅰ,pepsinogen Ⅰ)were compared between the two groups before and after treatment.Results:The total clinical efficiency of the observation group was higher than that of the control group(P＜0.05).After treatment,the epigastric swelling pain,qi stagnation and food accumulation,belching and acid swallo-wing,nausea and vomiting scores,TLR4,NF-κB,IL-6and TNF-α levels in both groups were decreased compared with those before treatment,and the observation group was lower than the control group(P＜0.05).The levels of gastrin,pepsinogen Ⅰ/pepsinogen Ⅰ and pepsinogen Ⅰ in 2groups after treatment were higher than before treatment,and the observation group exhibited a higher leavel than the control group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:Self-prepared Huowei Decoction combined with acupuncture has significant therapeutic effect on chronic atrophic gastritis,and can improve clinical symptoms and gastric mucosal function with good safety,which may be related to inhibiting TLR4inflammatory path-way.
Self-modulated HuoweitangPrickChronic atrophic gastritisTLR4 inflammatory pathwayGastric mucosal function
万方数据
维普
