Clinical efficacy of Shengyang Yiwei Decoction combined with PPI in the treatment of chronic atrophic gastritis and the influence of gastroscopy histology before and after treatment
Objective:To explore the clinical efficacy of Shengyang Yiwei Decoction combined with proton pump inhibitor(PPI)in the treatment of chronic atrophic gastritis and the influence of gastroscopy histology before and after treatment.Methods:From Au-gust 2022to July 2023,120patients with chronic atrophic gastritis who were treated in the traditional Chinese medicine(TCM)outpa-tient department and gastroenterology outpatient department of Jiaozhou Central Hospital of Qingdao were selected as the research ob-jects,and were divided into study group and control group by random number table method,with 60cases in each group.The control group was treated with conventional PPI therapy,and the study group was treated with Shengyang Yiwei Decoction on the basis of the control group.The efficacy,the degree of gastric mucosal lesion before and after treatment,TCM syndrome score and gastroscopy path-ological score before and after treatment were compared between the two groups,and the occurrence of adverse reactions was recorded.Results:The total effective rate of the study group was 91.67%,which was higher than that of the control group(78.33%).The difference between the two groups was statistically significant(P＜0.05).After treatment,the levels of IL-6,TNF-α and IL-1β in two groups were lower than before treatment,and the levels in study group were lower than those in control group,with statistical sig-nificance(P＜0.05).After treatment,the gastroscopy tissue of the two groups was compared,and the difference was statistically sig-nificant(P＜0.05).After treatment,the total scores of distension,stomachache,pain rejection,black stool,dark and stagnant face in two groups were lower than before treatment,and the study group was lower than the control group,the differences were statistically significant(P＜0.05).Conclusion:Shengyang Yiwei Decoction combined with PPI has a high effect in the treatment of chronic a-trophic gastritis,which can effectively improve the degree of gastric mucosal lesions and TCM syndrome scores,and reduce the level of serum inflammatory factors in patients,which has certain clinical application value.
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维普
