The therapeutic effect of Erchen decoction and Zexie decoction on hyperlipidemia and its influences on carotid plaque,serum TNF-α and IL-1β expression
Objective:To investigate the therapeutic effect of Erchen decoction and Zexie decoction on hyperlipidemia and its in-fluences on carotid plaque,serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)expression.Methods:From June 2022to February 2023,60patients with hyperlipidemia of Qi deficiency phlegm blood stasis type admitted to our hospital were randomly divided into the control group(30cases,treated with atorvastatin calcium)and the study group(30cases,treated with atorvastatin cal-cium combined with Erchen decoction and Zexie decoction),the clinical data of patients were collected,and the clinical efficacy,blood lipid level,carotid intima-media thickness(IMT),carotid intima plaque area,serum TNF-α,IL-1β level and adverse reac-tion rate of the two groups were compared.Results:Compared with the control group,the total effective rate of the study group was ob-viously higher(P＜0.05).Before treatment,there was no obvious difference in total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),IMT,carotid intimal plaque area,TNF-α and IL-1β levels between the two groups(P＞0.05);after treatment,the levels of TG,TC,LDL-C,IMT,carotid intimal plaque area,TNF-α and IL-1β in hyperlipidemia patients in both groups decreased,the level of HDL-C increased(P＜0.05),the improve-ment effect of the above indicators in the study group was more obvious(P＜0.05).Compared with the control group,the total inci-dence of adverse reactions in the study group decreased,but there was no obvious difference between the two groups(P＞0.05).Con-clusion:Erchen decoction combined with Zexie decoction has a definite effect on hyperlipidemia patients.It can reduce the area of ca-rotid plaque,improve the blood lipid level,and inhibit inflammatory reaction.It is safe and worthy of promotion.
HyperlipidemiaErchen decoction and Zexie decoctionCarotid plaqueAtorvastatin calciumTumor necrosis factor-α
万方数据
维普
