Effect of Yishen Jiedu Decoction combined with hemodialysis in the treatment of chronic renal failure and the influence on renal function,oxidative stress and micro-inflammatory response
Effect of Yishen Jiedu Decoction combined with hemodialysis in the treatment of chronic renal failure and the influence on renal function,oxidative stress and micro-inflammatory response
Objective:To observe the effect of Yishen Jiedu Decoction combined with hemodialysis(HD)in the treatment of chronic renal failure(CRF)and the influence on renal function,oxidative stress and micro-inflammatory response.Methods:Ninety patients with CRF admitted to the hospital from December 2021to December 2023were selected,and divided into a control group and an observation group by random number table method,with 45cases in each group.Patients in the control group were treated with HD,and patients in the observation group were treated with Yishen Jiedu Decoction on this basis.The two groups were compared on clinical effects,traditional Chinese medicine syndrome scores,renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],ox-idative stress[superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)],and micro-inflam-matory response[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]before and after treat-ment.The incidence rates of adverse reactions were calculated.Results:The total response rate of the observation group(88.89%)was higher than that of the control group(71.11%),and traditional Chinese medicine syndrome scores were lower than those of the control group(P＜0.05).After 1month of treatment,the levels of BUN,Scr,MDA,CRP,TNF-α,and IL-6in the two groups were reduced.The levels in the observation group were lower than those in the control group(P＜0.05).The levels of SOD and GSH-Px were higher than those before treatment,and the levels in the observation group were higher than those in the control group(P＜0.05).The incidence rates of adverse reactions in the two groups were comparable(P＞0.05).Conclusion:Yishen Jiedu Decoction combined with HD is effective in the treatment of patients with CRF,which can effectively improve clinical symptoms,renal function and oxida-tive stress,and help to alleviate micro-inflammatory response,with high safety.
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