Curative effect of Yiqi Shugan Huoxue Sanjie prescription combined with Xuanwu Zhitong ointment for acupoint appli-cation on cancer pain
Objective:To explore the curative effect of Yiqi Shugan Huoxue Sanjie prescription combined with Xuanwu Zhitong ointment for acupoint application on cancer pain.Methods:A total of 120patients with cancer pain treated in the hospital were enrolled between October 2021and December 2023.According to random number table method,they were divided into control group(60cases)and treatment group(60cases).The control group was treated with three-step analgesics,while treatment group was treated with Yiqi Shugan Huoxue Sanjie prescription combined with Xuanwu Zhitong ointment for acupoint application.After 4weeks of treatment,clini-cal curative effect,pain status(onset time and duration of analgesia,onset frequency of breakthrough pain),pain degree[numerical rating scale(NRS)],pain mediators[endothelin-1(ET-1),5-hydroxytryptamine(5-HT),β-endorphin(β-EP)]and quali-ty of life[World Health Organization Quality of Life Scale(WHOQOL-BREF)]before and after treatment,and occurrence of ad-verse reactions(constipation,nausea and vomiting,dizziness and headache)during treatment were compared between the two groups.Results:After treatment,response rate of treatment in treatment group was higher than that in control group(P＜0.05).After treat-ment,onset time and duration of analgesia,and onset frequency of breakthrough pain in treatment group were better than those in con-trol group(P＜0.05).After 4weeks of treatment,NRS scores were the lowest in both groups,and which were better in treatment group(P＜0.05).After treatment,levels of ET-1,5-HT and β-EP were decreased in both groups,and the decrease was greater in treat-ment group(P＜0.05).After 4weeks of treatment,WHOQOL-BREF scores were the lowest in both groups,and which were better in treatment group(P＜0.05).The incidence of adverse reactions in treatment group was lower than that in control group(P＜0.05).Conclusion:Yiqi Shugan Huoxue Sanjie prescription combined with Xuanwu Zhitong ointment for acupoint application can effectively improve levels of pain mediators,relieve pain and reduce onset frequency of pain in patients with cancer pain,which thus can improve quality of life,with significant curative effect and high safety.
Cancer painYiqi Shugan Huoxue Sanjie prescriptionXuanwu Zhitong ointmentAcupoint application
万方数据
维普
