Effect of Gegenqinlian decoction combined with Chuangtongan capsule on chronic periodontitis and its influence on Th17/Treg,Il-1β and PGE2levels in gingival crevicular fluid
Objective:To investigate the therapeutic effect of Gegenqinlian decoction combined with Chuangtongan capsule on chronic periodontitis and the effects on the levels of helper T cells 17/regulatory T cells(Th17/Treg),interleukin-1β(IL-1β)and prostaglandin E2(PGE2)in gingival crevicular fluid.Methods:A total of 114patients diagnosed with chronic periodontitis and admit-ted to the hospital between January 2021and January 2024were divided into two groups at random-one with 57cases and the other with a control group.Both patient groups received standard medical care.The control group was given Chuangtongan capsule on the basis of this treatment,and the observation group was given Gegenqinlian decoction on the basis of the control group,for 30days.Record re-spectively in the two groups before and after treatment in patients with the periodontal indexes,total effective rate,Th17/Treg,IL-1β and PGE2levels in gingival crevicular fluid.Result:After treatment,the scores of periodontal indexes in both groups were significantly decreased(P＜0.05).All of the observation group's periodontal scores were lower than those of the control group(P＜0.05).The total effective rate of observation group was 91.23%,which was higher than that of control group(P＜0.05).After treatment,the levels of Th17/Treg,IL-1β and PGE2in gingival creval fluid were significantly decreased(P＜0.05),and the index of the observation group reduce the amplitude is greater than the control group(P＜0.05).Conclusion:Gegenqinlian decoction combined with Chuangtongan capsule has a definite effect on chronic periodontitis,which can reduce the clinical symptoms and inflammatory reaction of patients and improve the periodontal symptoms.
Gegen Qinlian DecoctionChuangtongan capsuleChronic periodontitisTh17/TregPGE2
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维普
