Objective:To study the effects of Lizhong decoction combined with acupuncture on immune function,IL-17,Smad7and TGF-β1in patients with recurrent oral ulcer.Methods:Analysis was made on 106patients with recurrent aphthous ulcer who received treatment in the outpatient department of Stomatology of our hospital from May 2022to June 2023.According to the differences in treatment methods,106patients were divided into observation group(n=54)and control group(n=52),in which the control group was given acupuncture treatment on the basis of conventional treatment.Observation group was combined with Lizhong decoction flavor treatment on the basis of control group.The therapeutic effect and occurrence of adverse reactions,clinical symptoms(time to improve eating,time to heal ulcer and time to disappear ulcer pain)of the two groups were compared,and the immune function indicators(CD3+,CD4+,CD4+/CD8+),IL-17,Smad7and TGF-β1levels of the two groups were compared before and after treatment.Re-sults:The total treatment efficiency of observation group was significantly higher than that of control group(P＜0.05).After treat-ment,the improvement time of eating,ulcer healing time and ulcer pain disappearance time in the observation group were significantly lower than those in the control group(P＜0.05).Compared with before treatment,the levels of CD3+,CD4+and CD4+/CD8+in both groups were significantly increased after treatment,and the immune function indexes in the observation group were significantly better than those in the control group(P＜0.05).After treatment,the levels of IL-17,Smad7and TGF-β1in both groups were significantly improved,and the observation group was better than the control group,the difference was statistically significant(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＜0.05).Conclusion:Lizhong decoction combined with acupuncture can improve the therapeutic effect of recurrent oral ulcer and improve clinical symptoms effectively,which may be related to down-regulating the levels of IL-17and TGF-β1,up-regulating the expression of Smad7and enhancing immune function.
维普
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