Pyroptosis is a novel Gasdermin(GSDM)family protein-dependent programmed death mode,which is closely related to inflammatory response,involved in many diseases,and plays an important role in the body's immune response.Pyroptosis has been found to be strongly associated with gynecological diseases such as pelvic inflammatory disease,recurrent spontaneous abortion,endo-metriosis,premature ovarian insufficiency,and ovarian cancer.Pyroptosis is a double-edged sword compared to female reproductive system diseases.On the one hand,it can release cell contents to amplify inflammation and increase antibiotic resistance;on the other hand,it can inhibit the growth of ectopic endometrial cells and ovarian cancer cells,enhance the sensitivity of chemotherapy drugs,and enhance the therapeutic effect.In recent years,the research of traditional Chinese medicine(TCM)in treating gynecological dis-eases by regulating pyroptosis has been gradually increasing with remarkable efficacy.Therefore,the review summarizes the relation-ship between pyroptosis and the development of gynecological diseases,and summarizes the research on the intervention of active in-gredients of TCM and TCM compound in the treatment of gynecological related diseases,in order to provide a new way of thinking for exploring the pathogenesis of gynecological diseases and the treatment of TCM.
关键词
细胞焦亡/盆腔炎/复发性流产/子宫内膜异位症/早发性卵巢功能不全/卵巢癌/中医药
Key words
Pyroptosis/Pelvic inflammatory disease/Recurrent recurrent spontaneous abortion/Endometriosis/Premature o-varian insufficiency/Ovarian cancer
维普
万方数据