Research progress of Chinese medicine regulating PPARγ signaling pathway to prevent atherosclerosis based on the pathogenesis of heat toxicity and accumulation
AS is a chronic inflammatory disease and a major cause of coronary heart disease and stroke.Currently,there is no ef-fective treatment in western medicine,and whether it is possible to reverse or abate plaque is the hotpot and difficult point of research in this field.Heat and toxicity and accumulation are the important mechanisms of this disease:Qi stagnation,phlegm and blood stasis attach to the veins;internal heat becomes toxic,burns the heart veins,and accumulates into plaques.It is similar to the inflammatory mechanism in structure and function,and the dysregulation of PPARγ promotes the development of inflammation,promotes AS le-sions,and leads to plaque formation,making PPARγ a potential therapeutic target.Based on the pathomechanism of heat and toxicity and accumulation,this review discusses the mechanism of regulating PPARγ to prevent and control AS by clearing heat and removing toxins,resolving phlegm and dispersing knots,regulating qi and activating blood,and supporting the righteousness and dispelling e-vils,with the hope that it can provide a new way of thinking and methods for the treatment of AS.
万方数据
维普
