Mechanism of Astragalus propinquus S.Against Alzheimer's Disease Based on Network Pharmacology and Molecular Docking
To study the action mechanism of active components in Astragalus propinquus S.in treatment of Alzheimer's disease,methods of network pharmacology and molecular docking simulation were used to identify disease targets using relevant databases,construct target interaction and the drug-ingredient-target protein-disease network,and then conduct enrichment analysis of gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway in DAVID database,and the target sites were verified by molecular docking simulation.The results show that 20 active components of Astragalus propinquus S.against Alzheimer's disease are screened,among which quercetin,kaempferol,isorhamnetin,formononetin and 7-O-methylisomucronulatol are the key components.A total of 118 intersection targets are screened,including six key targets,which are enriched in biological processes such as inflammatory response cell apoptosis.A total of 180 signaling pathways are obtained,and the action mechanism is mainly related to TNF,PI3K-Akt,IL-17 and other pathways.
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