According to the requirements of a company, static strength calculation of LSR69B cooling fan at the rotating speed of 1260 r/min and 1380 r/min is carried out, then static strength assessment is done on the basis of allowable stress with the cool-ing fan in F state and T1 state. Fatigue strength calculation of the operating load from different directions of the cooling fan is made when the locomotive is running, and the fatigue life of LSR69B cooling fan is evaluated according to the IIW standard. The calculation of static strength and fatigue strength is based on the ANSYS software whose version is commercial from ANSYS companies of the United States.