We reviewed the research progress of composition,properties and health function of Colla Corii Asini polypeptide recently.It is found that the main component of Colla Corii Asini is type I collagen(COLIα1,COLIα2),type II collagen(COLIIα1)and high molecular weight proteins such as serum albumin(ALB)through bioinformatics research.Different research teams use biological enzymes to digest Colla Corii Asini protein to obtain small molecular weight polypeptide sequences of different lengths and types.Animal experiments show that Colla Corii Asini polypeptides play an important role in different levels of immune regulation;polypeptide can promote the increase of leukocyte and erythrocyte and hemoglobin in peripheral blood of anemic mice.At the same time,the antioxidant capacity of different Colla Corii Asini polypeptides was significantly different;In addition,polypeptide plays an important role in lowering blood pressure,improving Alzheimer's disease,inhibiting tumor,etc.The above results provide an important theoretical basis for future research on product development and clinical application of Colla Corii Asini polypeptide.
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