Network Pharmacology Analysis of Cordyceps cicadae in the Prevention and Treatment of Alzheimer's
In order to explore the mechanism of Cordyceps cicadae in the prevention and treatment of Alzheimer's disease,the network pharmacology and molecular docking analysis were carried out by searching Traditional Chinese Medicine Database and Analysis Platform(TCMSP),Symmap,Swiss Target Prediction,GeneCards,PubChem and other databases,using Cytasape 3.7.2,AutoDock,pymol and other software.A total of 4 important components and 289 potential targets were screened.The five pathways with more targets enriched by genome Encyclopedia(KEGG)were Cancer,Neuroactive ligand-receptor interaction,Chemical carcinogenic-receptor activation,Human cytomegalovirus infection and Alzheimer's disease.Molecular docking results verify that the 4 important components and 4 key targets can spontaneously combine,revealing C.cicadae could be uesd to prevent and treat Alzheimer's disease,through the key target such as MAPK3,MAPK1,HSP90AA1 and EGFR.
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