酿酒酵母转录因子Ask10p的研究进展
Research advances of transcription factor Ask10p in Saccharomyces cerevisiae
王赟 1袁嫒 1李晨豪 1徐丽丽1
作者信息
- 1. 齐鲁工业大学(山东省科学院) 生物工程学院 山东省微生物工程重点实验室,山东 济南 250353
- 折叠
摘要
酿酒酵母的转录因子Ask10p又称Rgc2p,作为RNA聚合酶II全酶的一个组分参与调节氧化应激反应,还可以作为水甘油通道蛋白Fps1p的正调节因子调节胞内渗透压平衡,近年来随着研究的不断深入,Ask10p已被证实在氧化应激、渗透压胁迫、热激胁迫和木糖代谢等方面发挥重要的调节作用,本文将概述Ask10p在酿酒酵母中的生物学功能及研究进展,并对其未来研究提出展望,以期为今后的研究提供理论参考.
Abstract
The transcription factor Ask10p of Saccharomyces cerevisiae,also known as Rgc2p,not only plays an important role in cell wall biosynthesis,but also participates in the regulation of oxidative stress as a component of the RNA polymerase II holoenzyme,and also participates in the regulation of osmotic balance as a positive regulator of the aquaglyceroporin Fps1p.In recent years,with the deepening of research,Ask10p has been confirmed to play an important regulatory role in oxidative stress,osmotic stress,acetate and toxic metal ion stress,and xylose metabolism.In this review,the biological functions and current research advances of Ask10p in Saccharomyces cerevisiae were presented,and the research directions were also prospected in order to provide reference for future research directions.
关键词
酿酒酵母/Ask10p/Fps1p/胁迫/木糖代谢Key words
Saccharomyces cerevisiae/Ask10p/Fps1p/stress/xylose metabolism引用本文复制引用
基金项目
国家自然科学基金(31801515)
山东省自然科学基金(ZR2019PC010)
出版年
2024
NETL
NSTL
维普
万方数据