Construction of hyperuricemia mice model and changes of immune homeostasis
The incidence of hyperuricemia is increasing year by year,and the impact of hyperuricemia on human health has become a hot and cutting-edge issue in the field of biomedicine.Existing studies have confirmed that long-term high uric acid levels can cause chronic damage to patients'joints and kidneys,but there are still few studies on the impact on immune homeostasis.This study successfully constructed three mouse models of hyperuricemia using different chemical inducers,and analyzed changes in uric acid,renal pathological changes,B cells in peripheral blood that are mainly responsible for humoral immunity,T cells that are responsible for cellular immunity,and innate proportion of immune cells such as NK cells and other immune cells was studied in detail.The results showed that compared with the normal control group,the proportion of B cells in the three hyperuricemia mouse models all decreased significantly,and the proportion of CD4+T cells,CD8+T cells and B cells in the 600 mg/kg high-dose xanthine exposure group declined particularly significant.This study reveals the important impact of hyperuricemia on the body from the perspective of immune homeostasis,provides a reference for the construction of a hyperuricemia model,and puts forward new ideas for the pathogenesis of gout and other diseases induced by hyperuricemia.
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