首页|H1型经颅磁刺激线圈结构设计对刺激效果的影响

H1型经颅磁刺激线圈结构设计对刺激效果的影响

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经颅磁刺激(transcranial magnetic stimulation,TMS)是一种无创、无痛、低成本实现大脑刺激的工具,在治疗许多精神疾病方面有效.H1 型线圈是一种TMS线圈.为实现深部脑组织刺激,基于现有的H1 型线圈,本研究提出一种由四匝线圈组成的一种简化的H形线圈,使用有限元分析计算球形头部模型内电场分布,并利用大脑内深度 20 mm处最大的电场强度Emax(20)与大脑表面最大电场强度Emax(0)的比值P(20)和Emax(0)研究H形线圈结构设计对刺激深度的影响.分析结果表明,H形线圈的刺激效果由线圈中两组线圈的结构、位置共同决定,通过调整线圈结构,最优的 H1 线圈对应的 P(20)和Emax(0)分别为 75.54%和 32.97 V/m.通过合理的结构设计,可实现在大脑表面最大电场强度较小的同时,刺激颅内深部组织.
Influence of H1 transcranial magnetic stimulation coil structure design on stimulation effect
Transcranial magnetic stimulation(TMS)is a non-invasive,painless,low-cost tool in brain stimulation,and has been effective in treating many mental disorders.The H1 coil is a promising tool to achieve deep brain tissue stimulation,which is beneficial for various diseases treatment caused by deep brain tissue lesions.Based on the commercial H1 coil,we proposed a simplified H-shaped coil composed of four turns.Finite element analysis was used to calculate the E field distribution in the spherical head model,the maximum electric field intensity at the depth of 20 mm in the brain and on the brain surface were noted as Emax(20)and Emax(0),separately.The proportion of Emax(20)in Emax(0)was used to characterize the influence of coil structure modification on stimulation depth.Simulation result revealed that,the H-shaped coil's stimulation effect was determined by both the structure and position of the two sets of coils.By adjusting the coil structure,the optimized H1 coil,P(20)and Emax(0)were 75.54%and 32.97 V/m,respective-ly.It is possible to stimulate deep intracranial tissues through reasonable structural design while minimize the maximum electric field in-tensity on the brain surface.

Transcranial magnetic stimulationH1 coilCoil structureStimulation depth

吴雅祥、廖绍伟、刘仲武、余红雅

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华南理工大学 电子与信息学院,广州 510641

华南理工大学 材料科学与工程学院,广州 510641

经颅磁刺激 H1型线圈 线圈结构 刺激深度

中国博士后科学基金项目

2023M731124

2024

生物医学工程研究
山东生物医学工程学会 山东省医疗器械研究所 山东省千佛山医院

生物医学工程研究

CSTPCD
影响因子:0.512
ISSN:1672-6278
年,卷(期):2024.43(2)
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