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基于能量的肿瘤温和热疗技术研究与应用进展

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近年来,基于能量的肿瘤温和热疗技术在临床应用中愈发广泛.温和热疗是一种利用热介质将治疗区域温度控制在 40~45℃,从而杀死肿瘤细胞的热疗技术.其治疗范围更广且不会灼伤周围正常组织.本文阐述了肿瘤温和热疗技术原理及设备的发展现状,介绍了耦合纳米粒子的温和热疗新技术,分析了热疗系统、肿瘤环境、纳米材料等因素对温和热疗效果的影响,阐释了其他疗法辅助温和热疗的增敏增效作用,并对温和热疗需要改进的关键技术进行了展望.
Progress in research and application of energy based mild hyperthermia for tumor
In recent years,the energy based on mild hyperthermia technology of tumor has been widely used in clinical applica-tions.Mild hyperthermia treatment is a thermal therapy technique of using thermal medium to control the temperature of the treated area at 40~45℃,thereby killing tumor cells.It has a wider therapeutic range and does not burn surrounding normal tissue.We describe the principle of mild hyperthermia technology and the development status of the equipment,introduce the new technology of mild hyperther-mia coupled with nanoparticles,analyze the influence of hyperthermia system,tumor environment,nanomaterials and other factors on the effect of mild hyperthermia,explain the sensitization and efficiency of other therapies assisted mild hyperthermia,and finally fore-cast the key technologies to be improved in mild hyperthermia.

Electromagnetic hyperthermiaThermoperfusionThermotherapy apparatusPhotothermal therapyMagnetic hyper-thermiaNano hyperthermia adjuvantCombination therapy

李汝洋、刘宝林

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上海理工大学 生物系统热科学研究所,上海 200093

电磁热疗 热灌注 热治疗仪 光热疗 磁热疗 纳米热疗佐剂 联合治疗

上海市肿瘤能量治疗技术与器械协同创新中心项目

2024

生物医学工程研究
山东生物医学工程学会 山东省医疗器械研究所 山东省千佛山医院

生物医学工程研究

CSTPCD
影响因子:0.512
ISSN:1672-6278
年,卷(期):2024.43(3)
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