For the preparation of the ability to promote osteogenesis and angiogenesis artificial porous biomaterial scaffolds and ex-plore its performance,we sythesized large-diameter mesoporous bioactive glasses(mBGPs)through hydrothermal synthesis and the in-corporation of pore-expanding agents.Bone morphogenetic protein-2(BMP-2)was loaded into the mesopores of mBGPs using vacu-um impregnation method.Subsequently,BMP-2/mBGPs and PLGA composite scaffolds were prepared by solvent casting particle leac-hing method.The material characterization results showed that mBGPs were hollow spherical shells with an amorphous phase structure and a disordered three-dimensional foam pore structure,which could continuously dissolve calcium ions,phosphate ions and silicate i-ons.Meanwhile,mBGPs had the ability of protein loading and slow release.The in vitro experimental results indicated that the BMP- 2/mBGPs/PLGA porous scaffold enhanced the adhesion and proliferation of rat bone marrow mesenchymal stem cells(rBMSCs)and significantly increased the secretion and expression of bioactive substances.In the rat alveolar bone defect model,the scaffold acceler-ates the growth rate and maturation of new bone tissue.
关键词
唇腭裂治疗/生物活性材料/介孔材料/生长因子负载/骨组织工程支架/骨缺损修复
Key words
Treatment of cleft lip and palate/Bioactive materials/Mesoporous materials/Loading growth factor/Bone tissue engi-neering scaffold/Repair of bone defects
维普
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