To explore the effect of magnetic induction hyperthermia in thyroid cancer model simulation study,we selected Helmholtz coil as the alternating magnetic field generating device and magnetic fluid as the magnetic heating material.According to Pennes bioheat transfer equation,three-dimensional modeling was carried out in COMSOL finite element simulation software to realize the coupling calculation of electric field and temperature field,and the distribution of electromagnetic field and heat field under magnetic induction hyperthermia in thyroid cancer area was obtained.The results showed that the maximum magnetic induction intensity of thyroid cancer tissue was 8 350.86 A/m,the maximum electric field intensity was 122.764 V/m,and the minimum electric field intensity was 0.758 V/m.When the magnetic fluid was added to thyroid cancer tissue,the tissue temperature rised sharply under the influence of the external alternating magnetic field,and the temperature became stable at about 400 s.The temperature of the whole thyroid cancer tissue reached more than 42℃,while the temperature of the central tissue of the tumor was about 46.929℃,and the temperature of the surrounding healthy tissue was within 42℃.This conclusion will provide an important basis for clinical application of magnetic induction hyperthermia for thyroid cancer.
关键词
甲状腺肿瘤/磁感应热疗/有限元分析/磁性纳米颗粒/亥姆霍兹线圈/多物理场
Key words
Thyroid tumors/Magnetic induction hyperthermia/Finite element analysis/Magnetic nanoparticles/Helmholtz coils/Multiphysics field
维普
万方数据