The optimal experimental conditions for calibrating potassium iodate titrant with sodium thiosulfate titration analysis water solution standard substance was studied using an automatic potentiometric titrator.This method has a fast electrode response speed,significant end point potential jump,small end point error,and a relative standard deviation of less than 0.2%.It can he used as a method for testing the uniformity,stability,and quantity verification of standard substances in potassium iodate titration analysis solutions.