Mechanism and clinical study of Tongluo decoction based on"formula target pathway"on cerebral infarction(Qi deficiency and blood stasis type)
Objective To investigate the mechanism of action of Tongluo decoction on cerebral infarction(Qi deficiency and blood stasis type)based on"formulation target pathway".Methods The components and targets of Tongluo decoction were obtained from TCMSP and HERB databases,and intersected with the target genes related to cerebral infarction in GeneCards database to determine the therapeutic targets.Constructing a therapeutic target protein interaction network online using the STRING database.Perform GO enrichment analysis and KEGG signaling pathway enrichment analysis on therapeutic targets using the DAVID 6.8 online tool.Results Tongluo decoction contains 492 active ingredients and 181 drug targets,with 280 disease targets for cerebral infarction and 29 drug disease intersection targets.Among them,IL6,INS,PPARG,HIF1A,NOS3,and VEGFA may be the core therapeutic targets.GO enrichment analysis and KEGG signaling pathway enrichment analysis showed that 29 therapeutic targets were significantly enriched in 60 biological processes,23 cellular components,13 molecular functions,and 21 KEGG signaling pathways(P＜0.01).Conclusion Tongluojian can prevent and treat cerebral infarction through multiple targets and pathways,and has the effects of improving cerebral circulation,inhibiting ischemia-reperfusion injury,improving neurological deficit,and anti atherosclerosis.
Tongluo decoctioncerebral infarctionnetwork pharmacologymechanism of action
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